Abstract Background: Leydig cell tumors account for less than 0.1% of all ovarian and are usually unilateral benign. They present mostly in postmenopausal women with symptoms hyperandrogenism. On the other hand, primary hyperparathyroidism (PHPT) is a relatively common endocrine disorder, prevalence one to seven cases per 1,000 adults. It most commonly presents as an isolated, sporadic clinical...

Key words: bone mineral density; hypercalciuria; panied by decreased osteoblastic surfaces, while others, have reported reduced bone formation, increased bone osteoporosis; renal stone disease; urolithiasis resorption and a severe mineralization defect [4]. In a recent retrospective analysis of bone mineral density by dual X-ray absorptiometry, we compared a

a 13 year- old girl had rickets clinically evident sicne she was 10 years of age. she received multiple doses of vitamin d3 without improvement.this patient manifested an unusal form of hypophosphatemic rickets with hypercalciuria. it is recommended that urinary calcium excretion be assessed in all patients with hypophosphatemic rickets before the initiation of any therapy

Hypercalciuria and hyperphosphaturia are present in long term and high dose regimens of glucocorticoid therapy. This study aims to evaluate the effect of niacin at its pharmacological dose on calcium and phosphate disturbances due to methylprednisolone administration in growing rats. Twenty one rats were randomly divided into three equal groups and treated as follows for 4 weeks: 1-Normal salin...

Dent's disease is a renal tubular disorder characterized by manifestations of proximal tubule dysfunction, including low-molecular-weight proteinuria, hypercalciuria, nephrolithiasis, nephrocalcinosis, and progressive renal failure. These features are generally found in males only, and may be present in early childhood, whereas female carriers may show a milder phenotype. Prevalence is unknown;...

Hypercalciuria in inbred genetic hypercalciuric stone-forming (GHS) rats is due, in part, to a decrease in renal tubule Ca reabsorption. Activation of the renal Ca receptor (CaR) may decrease renal tubule Ca reabsorption and cause hypercalciuria through suppression of Ca-sensitive potassium channel activity. Because the rat renal CaR gene is regulated by extracellular calcium and 1,25-dihydroxy...

About 12% of men and 5% of women of Western European descent develop at least one urinary stone during their lifetime. The incidence is somewhat less in individuals of sub-Saharan African or Asian descent, although there is a high incidence in the Middle Eastern countries. Calcium oxalate is a major constituent of about 70% of these stones. They are of multifactorial origin, with both genetic a...

Dent disease (DD) is a rare X-linked recessive renal tubulopathy characterised by low-molecular-weight proteinuria (LMWP), hypercalciuria, nephrocalcinosis and/or nephrolithiasis. DD is caused by mutations in both the CLCN5 and OCRL genes. CLCN5 encodes the electrogenic chloride/proton exchanger ClC-5 which is involved in the tubular reabsorption of albumin and LMW proteins, OCRL encodes the in...

Keywords: distal renal tubular acidosis, hypercalciuria; His urinary calcium excretion ranged from 2.8 to 4.1 mg/kg per day. No glucosuria, hyperaminoaciduria nerve deafness; nephrocalcinosis; Steinstrasse or hyperphosphaturia were found. After diagnosis of DRTA with nerve deafness, the patient was maintained on oral treatment with sodium bicarbonate at a dose