Hypertrophic obstructive cardiomyopathy (HOCM), which shows left ventricular outflow pressure gradient (LVPG), is often complicated with mitral regurgitation (MR). We examined a 62-year-old Japanese female with HOCM and MR. Ultrasound echocardiography showed severe MR, asymmetrical septal hypertrophy, systolic anterior movement of the mitral valve anterior leaflet, and left ventricular outflow ...

Hypertrophic cardiomyopathy (HCM) has evoked both fascination and controversy since its first modern description 50 years ago.1 Originally described as “functional aortic subvalvar stenosis” by Brock, the majority of articles about HCM in the ensuing first decade emanated from observations made in the operating room or in the cardiac catheterization laboratory.1 The actual cause of left ventric...

  Transient ischemic left ventricular dilation (TID) is a marker of severe and extensive coronary artery disease as well as an increased risk of adverse outcomes. The patients with more severe and extensive ischemia, multivessel-type of perfusion abnormality as well as patients with left anterior descending artery (LAD) territory perfusion abnormality have more probab...

Abstract Introduction In the last few years, genetic investigation has become an active part of diagnostic and therapeutic pathway cardiological patients with cardiomyopathies. Genetic assumes a key role in clinical–decision–making process proband acquiring potential changing clinical action. Patients referred for screening are affected by hypertrophic, arrhythmogenic dilated cardiomyopathy. fo...

A 50-year-old man was admitted for evaluation of syncope. Clinically, he had an irregular pulse and an ejection systolic murmur loudest at the left sternal border. Transthoracic echocardiography revealed hypertrophic cardiomyopathy (HCM) with midventricular obstruction and apical aneurysm with maximum pressure gradient greater than 74 mm Hg. Coronary angiogram showed normal coronary arteries. L...

A 73-year-old female patient with hypertrophic cardiomyopathy presented with angina. During catheterization, she developed atrial fibrillation with a rapid ventricular response, associated with severe haemodynamic compromise. Two transthoracic patches (pro-padz, Zoll Medical Corporation, USA) were positioned in the anterior–posterior position, but a rectilinear biphasic 200-J shock (M-series de...

Hypertrophic cardiomyopathy is a genetic cardiac disease with a particularly heterogeneous presentation and diverse natural history. Sudden and unexpected death has been recognized as a prominent and devastating consequence of hypertrophic cardiomyopathy since the initial description of this disease over 40 years ago. Many authors have emphasized that these catastrophic events occur not uncommo...

Citation: Monasky MM, Ciconte G, Anastasia L and Pappone C (2017) Commentary: Next Generation Sequencing and Linkage Analysis for the Molecular Diagnosis of a Novel Overlapping Syndrome Characterized by Hypertrophic Cardiomyopathy and Typical Electrical Instability of Brugada Syndrome. Front. Physiol. 8:1056. doi: 10.3389/fphys.2017.01056 Commentary: Next Generation Sequencing and Linkage Analy...

Two siblings from a family in which neurofibromatosis was inherited as an autosomal dominant had hypertrophic cardiomyopathy and neurofibromatosis. Idiopathic hypertrophic cardiomyopathy may have occurred by chance in two first degree relatives with neurofibromatosis. An alternative explantation is that these diseases are both manifestations of a common hereditary defect of neural crest tissue....