Small stature or growth retardation is a frequent problem in children, often leading to serious psychological repercussions. In some patients, as for instance in those with achondroplasia, severe hypothyroidism, or classical Turner's syndrome, the underlying disorder can easily be recognized. More often the growth retarded child presents no other symptoms, and the cause of dwarfism remains obsc...

Introduction The availability of hypothalamic-releasing hormones together with reliable assays of pituitary hormones in plasma have provided the means of accurate assessment of hypothalamic-pituitary function. A case is described of clinical hypopituitarism following radiotherapy to the head and neck, in which the use of these pituitary function tests has demonstrated damage at the hypothalamic...

A 14-year-old boy presented to the trauma unit at our tertiary hospital after sustaining a gunshot wound to the left eye. Clinical examination showed that he was alert and haemodynamically stable, but blind in the left eye, with no CSF rhinorrhoea. His pubertal status (Tanner stage S3) and height (1·7 m, 75th percentile) were appropriate for his chronological age. Skull radiography and a CT sca...

The association of psychiatric disorder with endocrine disturbance is well recognized and has been extensively described in the literature, particularly in relation to thyroid disorder. Nearly 100 cases of myxoedema with psychosis have been described since the Clinical Society of London reported mental changes in myxoedema in 1888 (Logothetis, 1963), and it is fairly frequently seen in clinical...

PURPOSE Congenital hypopituitarism is caused by mutations in pituitary transcription factors involved in the development of the hypothalamic-pituitary axis. Mutation frequencies of genes involved in congenital hypopituitarism are extremely low and vary substantially between ethnicities. This study was undertaken to compare the clinical, endocrinological, and radiological features of patients wi...

adioiodine (RAI) therapy for metastatic follicular cell–derived thyroid cancer (FCDC) requires elevated levels of serum TSH, usually achieved by withdrawal of thyroxine therapy. This is not possible in FCDC associated with hypopituitarism, because of the absence of endogenous TSH. However, the advent of recombinant human TSH (rhTSH) has made diagnostic 131I whole body scans and subsequent RAI t...

OBJECTIVE To formulate clinical practice guidelines for hormonal replacement in hypopituitarism in adults. PARTICIPANTS The participants include an Endocrine Society-appointed Task Force of six experts, a methodologist, and a medical writer. The American Association for Clinical Chemistry, the Pituitary Society, and the European Society of Endocrinology co-sponsored this guideline. EVIDENCE...

Serum anti-pituitary antibodies (APAs) to cytosolic antigens have been found in association with autoimmune hypophysitis, idiopathic hypopituitarism, and other autoimmune endocrinopathies. Here, an immunoblot method was used to search for serum autoantibody (AAb) reactivities against pituitary antigens, including nuclear and cytoskeletal proteins, in six patients with idiopathic hypopituitarism...

Adult patients with hypopituitarism are treated by the replacement of deficient hormones, although GH has not been substituted until March 2006 in Japan except for clinical trial. This study examines which hormonal status influences the prevalence of vascular risk disorders in hypopituitary adults. A sample of 263 adult patients with hypopituitarism was studied, among whom there were various ho...

Pseudohypoaldosteronism type II (PHA II) is a renal tubular disease that causes hyperkalemia, hypertension, and metabolic acidosis. Mutations in four genes (WNK4, WNK1, KLHL3, and CUL3) are known to cause PHA II. We report a patient with PHA II carrying a KLHL3 mutation, who also had congenital hypopituitarism. The patient, a 3-yr-old boy, experienced loss of consciousness at age 10 mo. He exhi...