BACKGROUND Leptin, body weight, body mass index (BMI) and other hormones in women with functional hypothalamic amenorrhoea (FHA) were investigated and the hypothesis proposed that energy imbalance is the predominant mechanism for leptin reduction in patients with FHA. METHODS Eighty-eight women with FHA and 65 age- and weight-matched controls were divided into homogeneous groups on the basis ...

Until 27 April 2006, the Netherlands Pharmacovigilance Centre Lareb received 7 reports of amenorrhea associated with the use of olanzapine. The time to onset varies from a few weeks to 10 months. The outcome was reported in 3 cases. One patient recovered after drug withdrawal and two patients did not recover; in one patient there was a dose increase to 15 mg once daily. In case D, hyperprolacti...

1. To recognize hypergonadotropic hypogonadism as part of the differential diagnosis of delayed puberty 2. To recognize premature ovarian failure as a cause of hypergonadrotropic hypogonadism 3. To recognize chemotherapy and cancer treatment modalities as etiologies of gonadal failure 4. To understand that it is hard to predict which patients will resume normal ovarian function after chemothera...

BACKGROUND & OBJECTIVE Uterine fibroid embolization is an effective treatment alternative for uterine fibroids. However, amenorrhea after uterine fibroid embolization occurs in some patients. This study was to investigate the causes of amenorrhea after uterine fibroid embolization. METHODS Bilateral transcatheter uterine artery embolization was performed in 487 patients with uterine fibroids....

Methods Clinical Records of 17 children (16 girls and 1 boy) were retrospectively analyzed over a period of 24 months (Mar 2012 to Mar 2014). All children satisfied the criteria for precocity based on clinical features, radiological assessment and GnRHa stimulation test. All 16 girls had idiopathic precocious puberty and the only boy had hypothalamic hamartoma. The mean age of presentation was ...

Introduction The sympathetic nervous system (SNS), as an important part of autonomic nervous system, through its hypothalamic neuroendocrine control of puberty, menarche and skeletal growth may contribute significantly to the pathogenesis of adolescent idiopathic scoliosis (AIS). Hyperactivity of the SNS has been reported to result in lower body mass index (BMI), lower bone mineral density (BMD...

Prader-Willi syndrome (PWS) is characterized by infantile lethargy and hypotonia causing poor feeding and failure to thrive, childhood obesity, short stature, and hypogonadism. The complex phenotype is most probably caused by a hypothalamic dysfunction that is responsible for the hormonal dysfunction. The resulting hypogonadism in PWS causes incomplete, delayed, and sometimes disordered puberta...

hypothalamic hamartoma (hh) is a rare intracranial lesion that usually presents with classic triad of central precocious puberty, gelastic epilepsy, and developmental delay. herein, a 14-year old boy is presented in whom the diagnosis of hh was made by magnetic resonance imaging. while he did not have any complain of precocious puberty, he surprisingly suffered from delay in puberty. the defini...

CONTEXT GH deficiency (GHD) associated with central precocious puberty (CPP) has been widely reported in cases of arachnoid cyst, septo-optic dysplasia, brain tumors, or after cerebral radiation therapy. However, idiopathic GHD associated with CPP has been reported in only one isolated case. OBJECTIVE To evaluate the occurrence and clinical features of the association of nonacquired GHD and C...