Independent component analysis (ICA) has been recently used as a model of natural image statistics and V1 simple cell receptive "elds. Here we show how to extend the ICA model to explain V1 topography as well. This is done by relaxing the independence assumption and ordering the basis vectors so that vectors with strong higher-order correlations are near each other. This is a new principle of t...

Although disruption of the microtubule (MT) array inhibits myogenesis in myocytes, the relationship between the assembly of microtubules (MT) and the organization of the contractile filaments is not clearly defined. We now report that the assembly of mature myofibrils in hypertrophic cardiac myocytes is disrupted by myoseverin, a compound previously shown to perturb the MT array in skeletal mus...

population. Several risk factors have been associated with the development of CTS including, age, body mass index (BMI), pregnancy, and wrist morphology. A single study has identified sleep position as a causative factor in the development of CTS. Our study evaluates the influence of age on the report of nighttime paresthesias and further examines the relationship between sleep position and rep...

Variants of chemically immortalized Syrian hamster embryo cells that had either retained (supB+) or lost (supB-) the ability to suppress tumorigenicity when hybridized with a fibrosarcoma cell line were subcloned. Both supB cell types are nontumorigenic; however, the supB- but not supB+ cells exhibit conditional anchorage-independent growth. Alterations of actin microfilament organization were ...

Flounders and cuttlefish have an impressive ability to change colouration, for camouflage and, in the case of cuttlefish, for communication. We pursue the hypothesis that these diverse patterns are created by combining a small number of distinct pattern modules. Independent component analysis (ICA) is a powerful tool for identifying independent sources of variation in linear mixtures of signals...

The author examined memory for text in terms of the independent influences of semantic knowledge associations and text organization. Semantic associations were operationalized as the semantic relatedness between individual text concepts and the text as a whole and assessed with latent semantic analysis. The author assessed text organization by simulating comprehension with the construction inte...

Assessing locomotor behavior is a standard methodology to characterize the behavioral phenotype of a genetic manipulation. Typically, levels of locomotor activity are measured using various methods that are based on the frequency of photobeam breaks or distance traveled as assessed by video-tracking systems. Locomotor behavior, however, is multi-dimensional and reflects the combined influences ...