objective: gelatinases are a large group of proteolytic enzymes that belong to the matrix metalloproteinases (mmps). mmps are a broad family of peptidases, which proteolyse the extracellular matrix and have an important role in inflammation. verapamil is a calcium channel blocker extensively used in the treatment of numerous cardiovascular diseases such as arrhythmia and hypertension. the anti-...

    Fibrates, as hypolipidemic drugs known as agonists of peroxisome proliferator-activated receptors, diminish inflammatory responses. Studies have shown that incorporation of a silicon atom into a drug structure improves its pharmacological potency, modifies its selectivity toward a given target, or changes its metabolic rate, in addition to increasing the lipophilicity of the compounds. A si...

The month of Ramadan, as a model of intermittent fasting, is a valuable opportunity to investigate the effects of dietary modifications on human metabolism. Fasting improves insulin sensitivity, reduces atherogenic risk, oxidative stress, and inflammation. Inflammation plays a key role in the pathogenesis of different disorders including atherosclerosis, metabolic syndrome and cardiovascular di...

leptadenia reticulata was reported to be used for several medicinal purposes. the present study was undertaken to evaluate anti-inflammatory, analgesic and lipid peroxidation inhibition activities of l. reticulata. the anti-inflammatory assay was performed by λ-carrageenan and formalin induced paw edema test. pro inflammatory mediators (il2, il6, tnf-α) in serum of treated and control organism ...

background: the pistachio is a nut produced by about 20 species of shrub. present-day studies show the health benefits of pistachio in preventing or treating diseases such as diabetes, cardiovascular diseases (cvds), cancer, multiple sclerosis (ms), and erectile dysfunction. materials and methods: medline / pubmed, and google scholar databases were searched using the keywords of pistacia vera, ...

Neuro-inflammation is the inflammation of nervous tissue due to oxidative stress, aging and autoimmunity and the major cause of Alzheimer's, Parkinson's and Huntington's disease. Periodontitis, the inflammation of the gums and supporting structures of the teeth, is a chronic peripheral immuno-inflammatory condition, affiliated with gram- negative, anaerobic bacteria that cause low-grade systemi...

objective: crocin and safranal are the main components of saffron, and have many biological functions such as anti-inflammatory and antioxidant activities. in the present study, we investigated the effects of crocin, safranal, morphine, diclofenac and naloxone in combined and separately on formalin-induced orofacial pain in rats. materials and methods: subcutaneous injection of a diluted formal...

The human amniotic membrane known as the innermost single epithelial-covered layer provides many applications such as applicable anti-inflammatory and anti-cancer effects. These immunomodulatory effects belongs to the epithelial cells, a type of epiblast-derived fetal stem cells which currently used for regenerative medicine and transplantation. These cells are collected by author-prepared faci...

objective(s) in recent years highly selective cox-2inhibitors were withdrawn from the market because of an increased risk of cardiovascular complications. in this study we were looking for potent compounds with moderate selectivity for cox-2. so, four analogues of 4, 5-diaryl-2-(2-alkylthio-5-imidazolyl) imidazole derivatives were synthesized and their anti-inflammatory and anti-nociceptive act...