The lung is a metabolically active organ that is engaged in secretion, clearance and other maintenance functions that require reducing potential, energy and substrates for biosynthesis. These metabolic requirements are met in part through uptake and catabolism of glucose which represents the major fuel utilized by lung tissues. Gluconeogenesis does not occur, and glycogen stores are limited so ...

KLEIN, SIGRID MI. (Brigham Young University, Provo, Utah) AND RICHARD D. SAGERS. Intermediary metabolism of Diplococcus glycinophilus. II. Enzymes of the acetate-generating system. J. Bacteriol. 83:121-126. 1962-The enzymatic steps in the conversion of glycine to acetate by Diplococcus glycinophilus were examined and the reaction rates of the individual steps compared with the maximal glycine f...

■ Abstract This review is intended to serve as a practical guide for geneticists to current applications of tandem mass spectrometry to newborn screening. By making dried-blood spot analysis more sensitive, specific, reliable, and inclusive, tandem mass spectrometry has improved the newborn detection of inborn errors of metabolism. Its innate ability to detect and quantify multiple analytes fro...

Most of the metabolic effects of fructose arc due to its rapid utilization by the liver and it by-passing the phosphofructokinase regulatory step in glycolysis, leading to far reaching consequences to carbohydrate and lipid metabolism. These consequences include immediate hepatic increases in pyruvate and lactate production, activation of pyruvate dehydrogenase, and a shift in balance from oxid...

The use of XML as a format for message exchange makes Web services well suited for composition of heterogeneous components. However, since clients must manage differences in message schemas between services, interoperability is still a significant problem. Interoperability currently can be supported through the use of transformations provided by a Web service intermediary. However, intermediary...