Previous reports from the Tuberculosis Chemotherapy Centre, Madras, have established that ambulatory treatment of pulmonary tuberculosis with the combination of isoniazid and PAS, administered daily, yields satisfactory results. However, in the usage of any unsupervised regimen, reliance must be placed on the co-operation of patients in self-administering their drugs. Irregularities in drug-tak...

Radiation plexopathy produces numbness, weakness, and reflex changes.1 Excess motor unit activity (EMUA) after irradiation manifests as myokymia and neuromyotonia in affected muscles.2,3 A 65-year-old woman presented with a pulling sensation in the left axilla and intermittent depression of the left arm of 3 to 4 months duration. Ten months earlier she had completed chemotherapy and radiation t...

Though an estimated 1 million new cases of tuberculosis (TB) occur in children worldwide each year, pediatric TB has not been given the same priority as its adult counterpart(1). Advances in diagnosis and treatment are lagging behind – the major limitation in performing treatment trials in children is the lack of a definitive gold standard for diagnosis and monitoring. As a result, regimens and...

Abstract Background Acral vascular syndrome clinically presents as digital ischemia with Raynaud’s phenomenon and erythromelalgia but can be rarely seen in the malignant condition. Patients may present pain, permanent blanching or cyanosis, desquamation ulceration of fingers. is associated lymphoid neoplasm smoking, autoimmune connective tissue diseases, vasculitis. Here, we describe a 79-year-...

BACKGROUND Intermittent application of chemotherapy and tyrosine kinase inhibitors may avoid antagonism between the two classes of drugs. This hypothesis was tested in a Phase II clinical trial. PATIENTS AND METHODS Eligible patients were nonsmokers or light smokers, chemo-naïve, with metastatic adenocarcinoma of the lung. TREATMENT 4 to 6 cycles of gemcitabine 1250 mg/m(2) on days 1 and 4,...

Carcinoids are the most common neuroendocrine tumours. They are usually slowly growing, located in the small intestine, secrete serotonin, and are characterized by long survival of patients, so prognosis is generally good. The most frequently encountered clinical presentations of carcinoids are intermittent abdominal pain and carcinoid syndrome (diarrhoea and flushing). Metastases worsen the pr...