نتایج جستجو برای: liver failure

تعداد نتایج: 664625  

Journal: :Annals of surgery 2004
Achilles A Demetriou Robert S Brown Ronald W Busuttil Jeffrey Fair Brendan M McGuire Philip Rosenthal Jan Schulte Am Esch Jan Lerut Scott L Nyberg Mauro Salizzoni Elizabeth A Fagan Bernard de Hemptinne Christoph E Broelsch Maurizio Muraca Joan Manuel Salmeron John M Rabkin Herold J Metselaar Daniel Pratt Manuel De La Mata Lawrence P McChesney Gregory T Everson Philip T Lavin Anthony C Stevens Zorina Pitkin Barry A Solomon

OBJECTIVE The HepatAssist liver support system is an extracorporeal porcine hepatocyte-based bioartificial liver (BAL). The safety and efficacy of the BAL were evaluated in a prospective, randomized, controlled, multicenter trial in patients with severe acute liver failure. SUMMARY BACKGROUND DATA In experimental animals with acute liver failure, we demonstrated beneficial effects of the BAL....

2004

Fulminant hepatic failure, a life threatening condition induced by massive hepatocellular necrosis may be associated with significant morbidity and mortality. A better understanding of the pathophysiology of this condition, associated with advances in intensive care management and liver transplantation have improved outcomes. This review describes recent advances in the management of fulminant ...

2010
Amit Sharma Adrian H Cotterell Daniel G Maluf Marc P Posner Robert A Fisher

INTRODUCTION Neonatal hemochromatosis is the most common cause of liver failure and liver transplantation in the newborn. The size of the infant determines the liver volume that can be transplanted safely without incurring complications arising from a large graft. Transplantation of monosegments II or III is a standard method for the newborns with liver failure. CASE PRESENTATION A three-week...

2006
Andres T Blei

An ideal therapy for acute liver failure (ALF) would be the successful promotion of liver regeneration, with spontaneous recovery from the disease. However, in spite of advances in our understanding of the process of regeneration1 and potential candidate compounds for clinical testing,2 we currently lack the ability to influence this process in the patient with ALF. Thus, therapeutic efforts ar...

Journal: :QJM : monthly journal of the Association of Physicians 2003
M Lewis P D Howdle

2017
Thomas Byrne

Acute liver disease presenting as jaundice is a common event occurring in pregnancy occurring in about 1 per 1000 deliveries. The most common cause of jaundice in pregnancy is viral hepatitis. In the developed world viral hepatitis causes about 2/3 s of cases of jaundice in several series. [1] The great majority of viral hepatitidies are of slow onset and course. They are rarely associated with...

Journal: :Gastroenterologia y hepatologia 2010
Angels Escorsell Mañosa Antoni Mas Ordeig

Acute-on-Chronic Liver Failure (ACLF) is a recently introduced term defined as severe acute deterioration of an established liver disease. This entity usually develops after an acute insult. The main clinical manifestations are hepatorenal syndrome, hepatic encephalopathy and organ failure, with a high risk of death in the short term. The true incidence of ACLF remains difficult to determine du...

Journal: :Journal of hepatology 2012
William Bernal Rajiv Jalan Alberto Quaglia Kenneth Simpson Julia Wendon Andrew Burroughs

Acute-on-chronic liver failure combines an acute deterioration in liver function in an individual with pre-existing chronic liver disease and hepatic and extrahepatic organ failures, and is associated with substantial short-term mortality. Common precipitants include bacterial and viral infections, alcoholic hepatitis, and surgery, but in more than 40% of patients, no precipitating event is ide...

Journal: :Annals of hepatology 2010
Fuat Ekiz Oguz Usküdar Zahide Simsek Ilhami Yüksel Omer Basar Akif Altinbas Osman Yüksel

Cefuroxime is a second-generation cephalosporin antibiotic. It is effective against susceptible bacteria causing infections of the middle ear, tonsillitis, throat infections, laryngitis, bronchitis, and pneumonia. It is also used in treating urinary tract infections, skin infections, and gonorrhea. It is a generally well tolerated antibiotic. Common adverse effects of cefuroxime axetil are diar...

Journal: :The Journal of biological chemistry 2005
Zhaoyu Li Luis B Agellon Dennis E Vance

In mammals, the only endogenous pathway for choline biosynthesis is the methylation of phosphatidylethanolamine to phosphatidylcholine (PC) by phosphatidylethanolamine N-methyltransferase (PEMT) coupled to PC degradation. Complete choline deprivation in mice by feeding Pemt(-/-) mice a choline-deficient (CD) diet decreases hepatic PC by 50% and is lethal within 5 days. PC secretion into bile is...

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