introduction valproic acid (vpa, valproate) is an eight-branch fatty acid and varies from other antiepileptic drugs. vpa use might lead to mild to severe hepatotoxicity. the aim of this study was to investigate valproic acid impact on liver transaminases at the beginning of vpa treatment and after three and six months of it. materials and methods this study was designed as a cross sectional pro...

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background: stearic acid is known as a potent anti-inflammatory lipid. this fatty acid has profound and diverse effects on liver metabolism. the aim of this study was to investigate the effect of stearic acid on markers of hepatocyte transplantation in rats with acetaminophen (apap)-induced liver damage. methods: wistar rats were randomly assigned to 10-day treatment. stearic acid was administe...

acute liver failure (alf) is an uncommon, devastating syndrome of which over 2000 cases occur annually in the usa, with a mortality rate of about 80%. alf is de_ned by the sudden onset of hepatic encephalopathy and coagulopathy (inr_1.5) in an otherwise healthy person. the most common etiologies are acute viral hepatitis a and b, medication overdose (e.g., acetaminophen) and idiosyncratic drug ...

background: mesenchymal stem cells (mscs) have been recently received increasing attention for cell-based therapy, especially in regenerative medicine. however, the low survival rate of these cells restricts their therapeutic applications. it is hypothesized that autophagy might play an important role in cellular homeostasis and survival. this study aims to investigate the regenerative potentia...

conclusions because 66% of students were anti-hav antibody negative and they will work as health care workers in future, our study suggest vaccinating all students accepted at aja university of medical sciences. results of total 270 students, 30 were female. their age ranged between 18 and 30 years old with the mean age of 20.58 years and just 34% of students had positive level of anti-hav anti...

introduction: cardiovascular abnormalities have been reported in liver cirrhosis (lc). in these patients, cardiac symptoms and physical signs occur as the liver functions worsen. cirrhosis is associated with hyper dynamic circulation and beta-adrenergic system changes responsible for the cardiovascular abnormalities. the purpose of the present study was to explore the echocardiographic findings...

background: closantel is a veterinary drug used as anthelmintic for ruminants while it is contraindicated for humans. this report describes a rare case of blindness, increased liver enzymes and coagulopathy following closantel poisoning. case report: a 5-year-old girl was presented with acute blindness following closantel poisoning. she was given mistakenly a dose of 500 mg/day (25mg/kg/day) fo...

conclusions etv and lam treatments had similar effects to improve 24 weeks survival rate of patients with chb-associated liver failure, but etv was associated with greater clinical improvement. both drugs were tolerated well during the treatment. it is suggested to perform further studies to verify the results. background nucleoside analogues are recommended as antiviral treatments for patients...

introduction one of the highly toxic mushrooms that are common in the northwest region of iran is amanita phalloides, which might result in renal or liver failure. case presentation this is a case report of a patient referred a few days after consumption of wild mushrooms to emergency department having gastrointestinal complaint whose experiments indicated liver and renal failure. the supportiv...