Objective(s): Phospholipase C ζ (PLCζ) is considered as a nominee for sperm associated oocyte activating factors and is located back-to-back with CAPZA3, an actin-capping protein controlling actin polymerization during spermiogenesis. They contain a common bidirectional promoter. The objective of this study was to identify individuals with parallel low expression of PLCζ and CAPZA3 mRNA, in hop...

Association of rs1800624 Polymorphism in Receptor for Advanced Glycation End Products Gene Promoter with the Risk Diabetic Nephropathy

ThirtyFrieswal lactating cows were screened for clinical and subclinical mastitis and subsequently classified into healthy, subclinically affected and clinically affected groups each group comprising of 10 cows. Polymorphism of cow lactoferrin (LTF) gene promoter was determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The results showed that LFT gene pro...

Saccharomyces cerevisiae accumulates trehalose as a stress metabolite in adverse environmental conditions. The synthesis and breakdown are important for the regulation of levels within yeast cell. Therefore, TPS1 NTH1 gene expressions tightly regulated during transcription also translation. Since both genes contain Stress Response Elements (STRE) promoter regions, they co-activated under Howeve...

Abstract Background Co-localized combinations of histone modifications (“chromatin states”) have been shown to correlate with promoter and enhancer activity. Changes in chromatin states over multiple time points state trajectories”) previously analyzed at enhancers separately. With the advent series Hi-C data it is now possible connect promoters analyze trajectories promoter-enhancer pairs. Res...

An anaerobic three-vessel continuous-flow culture system, which models the three major anatomical regions of the human colon, was used to study the persistence of Candida albicans in the presence of a faecal microbiota. During steady state conditions, overgrowth of C. albicans was prevented by commensal bacteria indigenous to the system. However antibiotics, such as tetracycline have the abilit...

HNF4alpha (hepatocyte nuclear factor 4alpha) belongs to a complex transcription factor network that is crucial for the function of hepatocytes and pancreatic beta-cells. In these cells, it activates the expression of a very large number of genes, including genes involved in the transport and metabolism of glucose and lipids. Mutations in the HNF4alpha gene correlate with MODY1 (maturity-onset d...

Background: We examine the GA-repeat core promoters of MECOM and GABRA3 in human embryonic kidney-293 cell line and show that those GA-repeats have promoter activity,and those different alleles of the repeats can significantly alter gene expression.We propose a novel role for GA-repeat core promoters to regulate gene expression in the genes involved in development and evolution. Materials and M...

Flower-Shaped Pt as Adhesion Promoter for IrOx Nanoparticles A large-area platinum (Pt) nanocrystal serves outstanding adhesion promoter low-content iridium (Ir), demonstrating a low impedance, high charge storage capacity and injection capacity. The Ir/Pt composites exhibit excellent biosafety chronic stability reported by Qi Zeng, Tianzhun Wu, co-workers in article number 2100965. This coatin...