The concerns about the possible risk of manufactured nanoparticles (NPs) have been raised recently. Nano- and micro-sized copper oxide (CO and CONP) are widely used in many industries. In this regard, in-vitro studies have demonstrated that CONP is a toxic compound in different cell lines. Despite their unique properties, NPs possess unexpected toxicity profiling relative to the bulk m...

Peroxisome proliferator-activated receptor (PPAR)-gamma ligands have been shown to inhibit human lung cancers by inducing apoptosis and differentiation. In the present study, we elucidated the apoptotic mechanism of PPARgamma activation in human lung cancers by using a novel PPARgamma agonist, 1-(trans-methylimino-N-oxy)-6-(2-morpholinoethoxy)-3-phenyl-(1H-indene-2-carboxylic acid ethyl ester (...

BACKGROUND The intestine is increasingly recognized as a primary effector of distant organ damage, such as the lung, after any abdominal surgery. Earlier studies have shown that surgical manipulation of the intestine induces generation of reactive oxygen species in the intestine, resulting in mucosal and lung damage. Because glutamine is preferentially used by the small intestine as an energy s...

Abstract The endoplasmic reticulum (ER) and mitochondria interact exchange material in healthy neurons. Mutants for the ER protein Creld show strong, Parkinson’s disease-like locomotion deficits. We found that facilitates phospholipid flux at ER-mitochondria interface, thereby enabling formation of hydrogen peroxide respiratory complex I, which is required dopaminergic neuron activity.

In the genetic modification of plant cells, mitochondrion is an important target in addition to nucleus and plastid. However, gene delivery into mitochondria cells has yet be established by conventional methods, such as particle bombardment, because small size high mobility mitochondria. To develop efficient mitochondria-targeting signal (MTS) that functions we designed artificial peptide (LURL...

Mitochondria of normal eukaryotic cells synthesize most ATP requirements needed to support cellular activity. They also participate in Ca and reactive oxygen species (ROS) signaling and in the execution of cell death. The structure and molecular composition of mitochondria vary largely among the different cellular types of mammals. The final mitochondrial phenotype results from gene expression ...

1,1-Dichloroethylene (DCE) causes pulmonary injury that is characterized by necrosis of bronchiolar Clara cells. Mitochondria have been identified as an early target in the toxic response. Because mitochondria have been implicated in both necrotic and apoptotic cell death, we have undertaken studies to test the hypothesis that DCE induces apoptosis, in addition to necrosis, in murine lung. A pr...

During the assessments of the correlation of the diseases and the microbiota of various clinical specimens, unique 16S ribosomal RNA (rRNA) gene sequences (less than 80% similarity to known bacterial type strains) were predominantly detected in a bronchoalveolar lavage fluid (BALF) specimen from a patient with chronic lower respiratory tract infection. The origin of this unique sequence is susp...

2-Aminophenoxazine-3-one (Phx-3)-induced apoptosis was investigated. Phx-3 suppressed the viability of human lung adenocarcinoma cell line A549 and induced cellular apoptosis 6 h after treatment. Prior to these events, intracellular pH (pHi) was rapidly decreased from pH 7.65 to 7.10 within 30 min when A549 cells were treated with 7 microM Phx-3. This intracellular acidification continued for 3...

there are few reported cases of endobronchial metastasis of pheochromocytoma literature. we present here a 56-year old woman who underwent left lower lobectomy of lung, following pneumonia with unresolved chest radiographs. computed tomography showed a lobulated soft tissue mass, measuring, 38×27 mm, at the perivascular space of anterior mediastinum. the resected specimen, showed lobulated tumo...