Sağlık hizmetlerinin zaman olarak ertelenmesinin mümkün olmaması, acil karşılanma zorunluluğu ve başarısızlığın insan hayatına mal olması gibi son derece önemli kendine has özelliği sağlık çalışanlarını şiddete uğrama açısından daha riskli hale getirmektedir. Nitekim çalışanlarına yönelik şiddeti; “şiddetin en vahşi şekli” yani bir nevi “bireysel terör” gören yasama organı 15.04.2020 tarihinde ...

Based on dynamic capability and contingency theory, authors examined the direct connection between Service innovation, Marketing innovation Customer satisfaction, interacting mechanism of competitive intensity. The research model hypotheses were developed from extant studies. Respondents 300 microfinance banks participated in survey. Analyses Smart PLS software showed that positively significan...

Regulated expression of recombinant genes in CD4+ cells is an important objective for gene therapy of AIDS, as these cells represent the principal target for viral replication of human immunodeficiency virus (HIV). We report here that specific combinations of CD4 cell-specific and viral regulatory elements can enhance expression of an antiviral gene product. Different viral regulatory elements ...

Skimmianine is a furoquinoline alkaloid present mainly in the Rutaceae family. It has been reported to have analgesic, antispastic, sedative, anti-inflammatory, and other pharmacologic activities. Despite its critical pharmacological function, its metabolite profiling is still unclear. In this study, the in vivo metabolite profiling of skimmianine in rats was investigated using ultra-performanc...

The potent positive inotropic effect, together with the relatively low safety risk of liguzinediol (LZDO), relative to currently available inotropic drugs, has prompted us to intensively research and develop LZDO as a potent positive inotropic agent. In this study, to obtain LZDO alternatives for oral chronic administration, a series of long-chain fatty carboxylic mono- and dual-esters of LZDO ...

We present the results of an observational study of the efficiency of deep mixing in globular cluster red giants as a function of stellar metallicity. We determine [C/Fe] abundances based on low-resolution spectra taken with the Kast spectrograph on the 3m Shane telescope at Lick Observatory. Spectra centered on the 4300Å CH absorption band were taken for 42 bright red giants in 11 Galactic glo...

Leucine-rich nuclear export signals (NESs) are recognized by the NES receptor exportin 1 and are central to the export of multiple shuttling proteins and RNAs. The export of messenger RNA in vertebrates was, however, thought to occur by a different pathway, because inhibition by injection of a synthetic Rev NES conjugate could not be demonstrated. Here we find that peptide conjugates composed o...