BACKGROUND Many physicians are still skeptic to treat opioid dependants, with or without maintenance treatment, for hepatitis C (HCV) because of concerns about psychiatric comorbidity, stability and adherence. In Norway, there are about 3,500 patients participating in the restrictive medication-assisted rehabilitation (LAR) programs in which all patients are given methadone or buprenorphine mai...

background: to measure suspected abuse of the methamphetamine (ma) among methadone maintenance treatment (mmt) patients in tehran, we studied all 206 patients who were admitted to mmt program from 2009 to 2015 to andishe-no addiction treatment clinic.  methods: ma presence was screened in one of the random urine samples routinely taken for tests of other drugs.  results: 70 (34.3%) patients wer...

a b s t r a c tintroduction: although decision-making processes have become a principal target of study among addiction researchers, few researches are published according to effects of different treatment methods on the cognitive processes underlying decision making up to now. utilizing cognitive modeling method, in this paper we examine the effects of methadone maintenance treatment (mmt) on ...

OBJECTIVES Methadone is the most frequently prescribed medication for the treatment of opioid dependence in the U.S., and questions relating to appropriate dosing of methadone remain an important issue. Given accumulating evidence suggesting an elevated prevalence of personality pathology in opioid dependent populations, as well as evidence of an association between Cluster B characteristics an...

Sir—Ritter et al .’s [1] claims their results show ‘LAAM maintenance has equivalent efficacy to methadone’ and ‘both treatments were equally effective in retaining clients in maintenance treatment’ are misleading. Their retention results actually favour methadone and their study was too small to identify confidently a clinically significant difference between the two maintenance drugs. The tria...

Methadone is a synthetic opioid frequently used in drug maintenance programs for heroin addicts. It prolongs the QT-interval and is mainly metabolized by the isoenzyme CYP3A4 of the hepatic cytochrome-P450-system, which is used by numerous other QT-prolonging agents. Its most severe side effect is the development of life-threatening Torsade de pointes ventricular tachycardia in the setting of a...

of prescribing injectable heroin and methadone to opiate-dependent drug users: associated health gains and harm reductions. Active heroin injectors' perceptions and use of methadone maintenance treatment: cynical performance or self-prescribed risk reduction? Substance It takes your heart: the image of methadone maintenance in the addict world and its effects on recruitment into treatment. Opia...

The relationship of methadone dose with post-mortem blood concentration was investigated using data collected from 1994 coronial cases in the Australian state of New South Wales. Data on 31 subjects were summarized using linear regression. The weight-adjusted methadone dose, gender, methadone maintenance treatment status and its interaction with adjusted-dose were all significant predictors of ...

Quality of Life (QOL) in opiate-addicted patients who are receiving methadone maintenance therapy is one of the important issues to be considered in the treatment of addiction. To determine a needs assessment using the PRECEDE model to find out factors related to QOL among Iranian male opiate addicts. This cross-sectional study was conducted in Kermanshah, Iran in 2013. A total of 762 male opia...