BACKGROUND AND PURPOSE The corpus callosum is an important predilection site for traumatic axonal injury but may be unevenly affected in head trauma. We hypothesized that there were local differences in axonal injury within the corpus callosum as investigated with diffusion tensor imaging (DTI), varying among patients with differing severity of traumatic brain injury (TBI). MATERIALS AND METH...

2 Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease in which upper and lower 3 motor neurons degenerate leading to muscle atrophy, paralysis and death within 3 to 5 years of 4 onset. While a small percentage of ALS cases are genetically linked, the majority are sporadic 5 with unknown origin. Currently, etiological links are associated with disease onset without 6 mechanistic ...

Traumatic brain injury (TBI) is a major cause of morbidity and mortality in children. After TBI, the vulnerable to additional injuries (secondary injuries) because disrupts normal autoregulatory defense mechanisms. These secondary play crucial role patient prognosis. Posttraumatic seizures are an important leading further damage injured brain. Continuous monitoring by electroencephalography (EE...

BACKGROUND Optic nerve sheath diameter (ONSD) evaluated in CT imaging as well as Rotterdam CT Score (RCTS) are proven independent predictors of outcome in patients with traumatic brain injury (TBI). To date, no study has correlated ONSD on admission CT scan with RCTS. MATERIAL/METHODS Retrospective cohort study comprised of consecutive patients undergoing CT imaging for traumatic brain injury...

The primary pathology associated with mild -traumatic brain injury (TBI) is selective axonal injury, which may characterize the vast majority of blast-induced TBIs. Axonal injuries in cases of mild TBI have been considered to be the main factors responsible for the long-lasting memory or attentional impairment in affected subjects. Among these axonal injuries, recent attention has been focused ...

Traumatic brain injury (TBI) is associated with psychiatric illness, suicidal ideation, suicide attempts, and completed suicide. We investigated the relationship between mild TBI and other risk factors for suicidal behavior in major depressive episode. We hypothesized that mild TBI would be associated with suicidal behavior at least partly because of shared risk factors that contribute to the d...

  Objective(s): Brain edema is one of the most serious causes of death within the first few days after trauma brain injury (TBI). In this study we have investigated the role of Shilajit on brain edema, blood-brain barrier (BBB) permeability, intracranial pressure (ICP) and neurologic outcomes following brain trauma.   Materials and Methods: Diffuse traumatic brain trauma was indu...

Traumatic brain injury (TBI) leading to 5 million deaths annually is 1 of the 5 major causes of morbidity and mortality worldwide. In Iran, accidents are the main cause of death in youth as well as a dominant factor in reducing quality of life. In developing countries TBI incidence as one of the worst consequences of these accidents is growing due to wide use of motor-vehicles. Therapeutic stra...

Abstract Introduction Traumatic brain injury (TBI) is a global public health burden. Although neurogenesis occurs post-injury, achieving long term survival of newly generated neurons remains elusive. High Mobility Group Box protein 1 (HMGB1) pivotal cytokine in hosting the neuro-inflammatory response to injury, but also mediates during physiological development. In this review, we examine curre...