Glutathione is an important antioxidant that plays role in myocardial remodeling. However, the exact mechanisms underlying effects of glutathione on heart failure are elusive. This study aimed to investigate treatment based network pharmacology technology. The gene expression profiles were downloaded from Gene Expression Omnibus database (GSE133054). Differentially expressed genes identified by...

Glial cell line-derived neurotrophic factor (GDNF) is released by glioma cells and promotes tumor growth. We have previously found that GDNF from the a chemoattractant for microglial cells, immune of central nervous system. Here we show increases matrix metalloproteinase (MMP) 9 MMP14 expression in cultured mixed sexes neonatal mice. The GDNF-induced MMP9 upregulation mediated family receptor a...

BACKGROUND Cardiac stress can trigger production of a 40-kDa peptide fragment derived from the amino terminus of the cardiac myosin-binding protein C. Cardiac stress, as well as cMyBP-C mutations, can trigger production of 1 such truncated protein fragment, a 40-kDa peptide fragment derived from the amino terminus of cMyBP-C. Genetic expression of this 40-kDa fragment in mouse cardiomyocytes (c...

Soybean isoflavone genistein has multiple anticancer properties and its pro-apoptotic and anti-proliferative effects have been studied in different cancer cells. However, the mechanisms of action of genistein and its molecular targets on human colon cells have not been fully elucidated. Therefore, caspase-3 and p38 mitogen-activated protein kinase (p38 MAPK) as the main therapeutic targets...

Mitogen-Activated Protein Kinases (MAPKs) cascade plays an important role in regulating plant growth and development, generating cellular responses to the extracellular stimuli. MAPKs cascade mainly consist of three sub-families i.e. mitogen-activated protein kinase kinase kinase (MAPKKK), mitogen-activated protein kinase kinase (MAPKK) and mitogen activated protein kinase (MAPK), several casca...

Maintaining cellular calcium (Ca2+) homeostasis is essential for many aspects of life. The high-osmolarity glycerol (HOG) mitogen-activated protein kinase (MAPK) pathway responsible signal integration and transduction plays crucial roles in environmental adaptation, especially the response to osmotic stress. Hog1 activated by transient Ca2+ increase yeast, but functions HOG are largely unknown....