We report the access to an acyclic iso-secologanin aglycone analogue relevant secoiridoids and monoterpene indole alkaloids. Its synthesis involved regioselective allylic alkylation of a linear dienyl carbonate with dimethyl malonate, which was catalyzed by iridium complex, anti-Markovnikov Wacker-type oxidation terminal alkene branched product that obtained. The thus-formed aldehyde engaged in...

The novel skeleton compounds, chamaecypanone C (3) and obtunorlignan A (4) were isolated from the heartwood of Chamaecyparis obtusa var. formosana. The structure of 3 was elucidated as a dimeric of monoterpene and norlignan with tricyclo[5.2.2.0]undecane and the structure of 4 was elucidated as a norlignan skeleton by spectroscopic methods. Compound 3 exhibits potent cytotoxic activity against ...

Background & Aim:Nepeta racemosa is an herbal and medicinal plant and this report aims to   identify chemical compositions of the essential oils and volatiles of its   aerial parts through classical and advanced methods.  Experimental: Chemical profiles of the essential oils and volatile compounds from the aerial parts of Nepeta racemosa obtai...

Stereoisomers of the monoterpene epoxycarvone (EC), namely (+)-cis-EC, (-)-cis-EC, (+)-trans-EC, and (-)-trans-EC, were comparatively evaluated for anticonvulsant activity in specific methodologies. In the pentylenetetrazole (PTZ)-induced anticonvulsant test, all of the stereoisomers (at 300 mg/kg) increased the latency to seizure onset, and afforded 100% protection against the death of the ani...