The synthesis and use of polymer cubosomes have received significant attention in recent years. Polymer are highly stable colloidal particles with triply periodic minimal surface. Inherently, several advantages over other nanostructures like micelles vesicles as they quite uniform porous structures. Due to the large specific surface area interior bicontinuous nature, capacity load amounts hydro...

Currently, the solid lipid nanoparticles (SLNs) are utilized as a novel approach for controlled drug delivery system (CDDS). Tacrolimus (TCM), lipophilic drug, can easily be encapsulated in hydrophobic core of these SLNs using nanoprecipitation technique. The current aim was to develop release Poloxamer (PLX) facilitated TCM loaded (PLX/TCM-SLNs), followed by their physicochemical evaluations, ...

The purpose of the present study was to formulate and evaluate donepezil loaded bio-nanoparticles for effective treatment of Alzheimer’s disease. For the preparation of bio-nanoparticles biomaterial was isolated from fruits of Carica papaya by an economic method. The biomaterial recovered from the concentrate was subjected for various physicochemical properties like color, solubility, ...

Purpose: To formulate Eudragit RS 100-based nanoparticles containing metronidazole (MTZ NPs) and incorporate them into hydrogels using different gelling agents for controlled release in the buccal mucosa.
 Method: MTZ NPs were fabricated nanoprecipitation method. (1 % w/w) introduced excipients. Physicochemical properties of NPs, mucoadhesive strength spreadability hydrogels, ex vivo perme...

Background: Psoriasis is a widespread chronic disease affecting 1-3% of total population and in most cases, treated by topical application corticosteroids. Though, the route very demanding because physicochemical nature diseased stratum corneum so no, single treatment works for every patient. The oral evidence harsh side effects systemic immunosuppression which can be avoided route. Objectives:...

Gliclazide is an oral hypoglycaemic agent used for the treatment of non-insulin dependent diabetes mellitus T2DM. has low solubility in stomach and poor absorption bioavailability. The pH-dependent gliclazide influences intra- inter-subject variability. purpose this study was to develop, optimize evaluate pH-sensitive nanoparticles (NPs) based on Eudragit® S100 polymer delivery (GLZ) attempt im...