We have studied the role of prostaglandin E2 on the modulation of tumor necrosis factor by immunologically elicited and lipopolysaccharide treated murine macrophages. Indomethacin, a potent inhibitor of prostaglandin E2 production, caused a dose dependent augmentation of lipopolysaccharide induced tumor necrosis factor production (2-3 fold at 10(-7) molar). Tumor necrosis factor was released in...

background:  new discoveries about the pathophysiology changed the concept that all forms of osteoarthritis are alike; this lead to the delineation of different phenotypes such as age, trauma or obese related forms. we aim to compare soluble mediator profiles in primary knee and posttraumatic wrist osteoarthritis. based on the general faster progression rate of wrist osteoarthritis, we hypothes...

OBJECTIVES To determine the effect of severe sepsis on monocyte tumor necrosis factor-α-converting enzyme baseline and inducible activity profiles. DESIGN Observational clinical study. SETTING Mixed surgical/medical teaching hospital ICU. PATIENTS Sixteen patients with severe sepsis, 15 healthy volunteers, and eight critically ill patients with noninfectious systemic inflammatory response...

Tumor necrosis factor-alpha is thought to be one of the most important inflammatory cytokines associated with the demyelinating disease multiple sclerosis. We determined whether neurotrophins could protect oligodendrocytes from tumor necrosis factor-alpha-mediated cytotoxicity. Among the neurotrophins tested, nerve growth factor was most effective at preventing cell death. Nerve growth factor a...

OBJECTIVE To investigate the possible role of tumor necrosis factor in mediating cardiotoxicity following venom injection in a rat. DESIGN A randomized controlled experimental study using a Langendorff isolated heart model. SETTING Animal laboratory. SUBJECTS Adult male Wistar rats. INTERVENTIONS The control group (n = 10) was injected with saline only. Each animal in the experimental g...