Background Alzheimer’s is most common neurodegenerative disorder characterized by memory loss due to accumulation of amyloid- β fibrils. There are different pathologies that count for AD like neuro-inflammation. This study highlights the role oxidative stress and inflammation in progression whereas Perillyl alcohol (POH) shows ant & anti-inflammatory properties. Method 54 Sprague Dawley ICV-STZ...

introduction: the inflammatory response requires a coordinated integration of various signaling pathway including cyclooxygenase (cox). cox catalyzes the formation of prostaglandins from arachidonic acid. among prostaglandins, 15-deoxy-d12, 14-prostaglandin j2 (15d-pgj2), an endogenous ligand of peroxisome proliferator-activated receptor-gamma (ppar-γ), has been demonstrated to have anti-inflam...