Studies on neural development and neuronal regeneration after injury are mainly based animal models. The establishment of pluripotent stem cell (PSC) technology, however, opened new perspectives for better understanding these processes in human models by providing unlimited source hard-to-obtain tissues. Here, we aimed at identifying the molecular factors that confine modulate an early step reg...

Modeling the behavior of Non-Player Characters (NPCs) so that they can act properly in an artificial world is a difficult, yet essential task in the development of modern computer games, often requiring neverending adjustments of handwritten rules in a way to enable NPCs to perform well in the game world. This paper introduces an evolutionary method relying on highlevel rule-based behaviors, ge...

a decade ago, sub-saharan africa accounted for 24% of the global disease burden but was served by only 4% of the global health workforce. the chronic shortage of medical doctors has led other health professionals especially nurses to perform the role of healthcare providers. these health workers have been variously named clinical officers, health officers, physician assistants, nurse practition...

A decade ago, sub-Saharan Africa accounted for 24% of the global disease burden but was served by only 4% of the global health workforce. The chronic shortage of medical doctors has led other health professionals especially nurses to perform the role of healthcare providers. These health workers have been variously named clinical officers, health officers, physician assistants, nurse practition...

Purpose/Objective(s) Recurrence and metastasis of nasopharyngeal carcinoma (NP) is closely related to immune escape. It known that LMP1 promotes the escape cells (NPCs) by controlling expression PD-L1. However, underlying molecular mechanisms remain be fully characterized. Materials/Methods At first, we screened transcription factor which can induce, find regulates PD-L1, furt...

NUP116 encodes a 116-kD yeast nuclear pore complex (NPC) protein that is not essential but its deletion (nup116 delta) slows cell growth at 23 degrees C and is lethal at 37 degrees C (Wente, S. R., M. P. Rout, and G. Blobel. 1992. J. Cell Biol. 119:705-723). Electron microscopic analysis of nup116 delta cells shifted to growth at 37 degrees C revealed striking perturbations of the nuclear envel...

Multipotent, self-renewing neural stem cells and their progeny [collectively referred to as neural precursor cells (NPCs)] represent a population of cells with great promise for CNS repair. To effectively harness their potential for therapeutic applications, the factors that regulate NPC behavior and/or fate must be well understood. The ability of immunomodulatory molecules to affect NPC behavi...

Cellular transplantation in the form of bone marrow has been one of the primary treatments of many lysosomal storage diseases (LSDs). Although bone marrow transplantation can help central nervous system manifestations in some cases, it has little impact in many LSD patients. Canine models of neurogenetic LSDs provide the opportunity for modeling central nervous system transplantation strategies...

Directed differentiation of human embryonic stem cells (hESCs) into specific somatic cells holds great promise for cell replacement therapies. However, it is unclear if in vitro hESC differentiation causes any epigenetic abnormality such as hypermethylation of CpG islands. Using a differential methylation hybridization method, we identified 65 CpG islands (out of 4608 CpG islands or 1.4%) that ...