The study of human protoporphyrinogen oxidase (hPPO) inhibition can contribute significantly to a better understanding some pathogeneses (e.g., porphyria, herbicide exposure) and the development anticancer agents. Therefore, we prepared new potential inhibitors with Schiff base structural motifs (2-hydroxybenzaldehyde-based bases 9–13 chromanone derivatives 17–19) as structurally relevant PPO h...

A homologous series of aromatic esters, 4-nalkanoyloxybenzylidene-4’-bromoanilines, nABBA, consisting of two 1,4-disubstituted phenyl cores and a Schiff base central linkage was synthesized. All the members can be differed by the number of carbon atoms at terminal alkanoyloxy chain (CnH2n-1COO-, n = 2, 6, 18). The molecular structure of nABBA was confirmed with infrared spectroscopy, nuclear ma...

The pathways involved in the biosynthesis of the benzoquinone ring of the ubiquinones have not been established. Recognition of the inability of mammals to synthesize aromatic rings de nova has led to the supposition that, in mammals, the benzoquinone ring of the ubiquinones arises from dietary aromatic amino acids. In support of this theory, Bentley et al. (1) administered phenylalanine-U-Cl4 ...

A method of assessing the hydrocyanic acid potential (HCN-p) of sudangrass [Sorghum sudanense (Piper) ~tapfl ~nd sorg~um [So bicolor (L.) Moench] seedlings IS described, ThIS procedure is based on the detennination of p-hydroxybenzaldehyde (p·HB), which is released upo,:, hydrolysis of dhurrin, the cyanogen normally prese;"t m plan~s of Sorghum species. Extraction and hydrolvs~s of d~urnn are a...

3-hydroxybenzaldehyde (3-HBA) is a precursor compound for phenolic compounds like Protocatechuic aldehyde (PCA). From recent reports, PCA has shown vasculoprotective potency, but the effects of 3-HBA remain unclear. The aim of this study is to investigate the vasculoprotective effects of 3-HBA in endothelial cells, vascular smooth muscle cells and various animal models. We tested effects of 3-H...

The main contaminant at many military sites is 2,4,6trinitrotoluene (TNT). This explosive remains stable in the environment, and because it is toxic, there is an urgent need for remediation to clean up contaminated sites. Pseudomonas sp. JLR11 is a soil isolate able to use nitrate, TNT, or both as the N source under anaerobic conditions. At least two polypeptides were detected in cell-free extr...

Epichloe typhina is an endophytic fungus, while Cladosporium phlei is a pathogenic fungus of the timothy plant (Phleum pretense L.). We found two activities in the culture filtrate of E. typhina: one stimulated the pathogenic fungus, C. phlei, to produce phleichrome and the other inhibited its growth. The active ingredients that stimulated the production of phleichrome and inhibited the growth ...