PURPOSE To examine associations between corneal mechanical thresholds and metrics of dry eye. METHODS This was a cross-sectional study of individuals seen in the Miami Veterans Affairs eye clinic. The evaluation consisted of questionnaires regarding dry eye symptoms and ocular pain, corneal mechanical detection and pain thresholds, and a comprehensive ocular surface examination. The main outc...

To the Editor: Alkali burn (AB), one of the most devastating types of ocular trauma, often develops secondary dry eye, which, in turn, worsens ocular surface disorder. The corneal epithelium is the first defensive line of the eye involved in pathogen-associated molecular pattern recognition that leads to robust innate immune responses. However, how damage-associated molecular pattern recognitio...

Axenfeld Rieger Syndrome is anterior segment dysgenesis characterized by posterior embryotoxon and of the chamber. Developmental abnormalities angle cause increased resistance to outflow. Ocular hypertension a complication in almost 50% cases. It an autosomal dominant disease its prevalence between 50,000 100,000 newborns per year. The main associated affected genes are FOXC1 PITX2, occurring 4...

Noonan syndrome (NS) is a heterogeneous autosomal dominant disorder caused by germline mutations in genes belonging RAS-MAPK pathway. Herein, we described two patients with developmental delay and syndromic features from Central Brazil diagnosed NS using an exome sequencing target gene panel. Germline mutation that participates the signaling pathway are associated disorders share particular cli...

the histopathologic diagnosis of orbital and ocular adnexal lymphoproliferative lesions is difficult, resulting controversy in classification, determining benignity or malignancy of them and treatment modality selection. we designed the following study to evaluate clinical, histopathologic and if necessary immunochemical features of them in decreasing indeterminate cases. the study includes 51 ...

Purpose: The present study aimed to review the effect of dehydration during Ramadan fasting on the health and ocular parameters leading to changes in eye function. Methods: Articles included in the study were taken from Pub Med, Ovid, Web of Science and Google Scholar up to 2014.Related articles were also obtained from scientific journals in fasting and eye. Results: Dehydration and nutrition c...

PURPOSE Noninfectious uveitis results in vision loss and ocular complications without adequate treatment. We compared the risk of developing ocular complications between patients with noninfectious intermediate uveitis, posterior uveitis, or panuveitis (NIIPPU) and matched controls. DESIGN Retrospective analysis of insurance claims data (OptumHealth, Eden Prairie, MN; January 1, 1998-March 31...

Eyedrops often contain additives other than active pharmaceutical ingredients, such as preservatives. The most frequently used preservative is benzalkonium chloride (BAC). When the ocular surface exposed to eyedrops, ingredients and can cause corneal epithelial disorder. Particularly in clinical settings, there great interest disorders resulting from use of glaucoma which inevitable when instil...