Oxidative stress plays a critical role in the pathogenesis of asthma. To effectively control oxidative stress in asthmatics, it is important to investigate the precise intracellular mechanism by which the development of immunity, rather than immune tolerance and progression of airway inflammation, is induced. In this article, we suggest that protein tyrosine phosphatases, as intracellular negat...

Despite the significance of oxidative damage for carcinogenesis, the molecular mechanisms that lead to increased susceptibility of tissues to oxidative stress are not well-understood. We now report a link between loss of protection against oxidative damage and loss-of-function of Nkx3.1, a homeobox gene that is known to be required for prostatic epithelial differentiation and suppression of pro...

background: oxidative stress is described as the formation of toxic effect due to the deficiency of cellular antioxidative level toward the level of reactive oxygen species (ros). the excess production of ros or the decrease in the antioxidative defense system could be the cause for oxidative stress. 7,12-dimethylbenz[a]anthracene (dmba) that is known to be the major cause the increment in lipi...

Oxidative stress is an imbalance between oxidants and antioxidants in favor of the oxidants, resulting disruption redox signaling control causing molecular damage. related to a variety diseases, for example, cardiovascular neurodegenerative infections, cancer. It might be that oxidative stress, and, more specifically, reactive oxygen species (ROS), affects longevity subtle way through signaling...

Biochemical study in the effect of alcoholic extract Thymus vulgaris lowering incluced toxicity liver and kidney Albino Mice mice. The am this is to investigate ethanolic on levels enzymes Thirty albino mice average weight (25-30)gm were divided into 5 groups as follow:group1; has given normal diet control group.
 group2; (injected with carbon tetrachloride CCl4), group3 CCl4 + 0.5mg/ml sa...

Non-alcoholic fatty liver disease (NAFLD) is associated with prediabetes and can be treated by using a combination of metformin dietary modification. However, people often fail to adhere modifications become more dependent on pharmaceutical intervention, this affects the effectiveness drug. In study, we investigated effects rhenium (V) compound uracil-derived ligands health in diet-induced pred...

BACKGROUND Sonchus asper (L.) Hill, (Asteraceae) is used in Pakistan as a traditional ("folk") medicine for the treatment of hormonal disorders and oxidative stress. The present study was aimed to evaluate the efficacy of Sonchus asper (L.) Hill, (Asteraceae) methanolic extract (SAME) on hormonal dysfunction in thyroid tissue after carbon tetrachloride (CCl4)-induced oxidative stress. METHODS...

Peptide deformylase (PDF) catalyses the removal of the formyl group from the first methionine of nascent proteins. Type 1 PDFs are found in bacteria and have orthologues in most eukaryotes. Type 2 PDFs are restricted to bacteria. Type 3 enzymes are found in Archaea and trypanosomatids and have not been studied experimentally yet. Thus, TbPDF1 and TbPDF2, the two PDF orthologues of the parasitic...

Cytochrome P450 NADPH-reductase (P450R), inducible synthase (iNOS) and xanthine oxidase play an important role in the antracycline-related cardiotoxicity. The expression of P450R and iNOS is regulated by triiodothyronine. The aim of this study was to evaluate the effect of methimazole-induced hypothyreosis on oxidative stress secondary to doxorubicin administration. 48 hours after methimazole g...