To develop a safe and efficient Aβ vaccine for Alzheimer's disease, we constructed a plasmid DNA vaccine encoding ten repeats of Aβ3-10 and three copies of C3d-p28 as a molecular adjuvant and administered it intramuscularly in 12-month-old female Tg-APPswe/PSEN1dE9 mice. Therapeutic immunization with p(Aβ3-10)10-C3d-p28.3 stimulated a Th2 immune response that elicited therapeutic levels of anti...

It shows that a possible relationship between anxiety and dissociation disorder. Dissociative disorder includes dissociative amnesia, depersonalization and the realization that they can occur when a person exposes to severe psychiatric stressful events that they have strong negative emotion for him and then he cannot cope with them, so use unsuitable strategies for coping such as memory loss (d...

Irresistible Materials (IM) is developing novel resist systems based on the multi-trigger concept, which incorporates a dose dependent quenching-like behaviour. In this study, we present results that have been obtained using Multi Trigger Resists (MTR) by performing EUV exposures ASML NXE scanner at IMEC. The MTR negative tone high opacity crosslinking incorporating. Pitch 28nm dense patterns c...

Microglia activation is recognized as the hallmark of neuroinflammation. However, the activation profile and phenotype changes of microglia during the process of retinal degeneration are poorly understood. This study aimed to elucidate the time-spatial pattern of microglia distribution and characterize the polarized phenotype of activated microglia during retinal neuroinflammation and degenerat...