OBJECTIVE Pathological worry is considered to be a defining feature for Generalized Anxiety Disorder (GAD). The Penn State Worry Questionnaire (PSWQ) is an instrument for assessing pathological worry. Two earlier studies demonstrated the suitability of the PSWQ as screening instrument for GAD in outpatient and non-clinical samples. This study examined the suitability of the PSWQ as a screening ...

We have developed a new computer-aided diagnostic system for differentiating oral borderline malignancies in hematoxylin-eosin stained microscopic images. Epithelial dysplasia and carcinoma in-situ (CIS) of oral mucosa are two different borderline grades similar to each other, and it is difficult to distinguish between them. A new image processing and analysis method has been applied to a varie...

The dramatic remissions occurring in rheumatoid arthritis during the adminis-tration of cortisone or ACTH are now familiar observations. In addition to the -volume of clinical and biochemical data already collected, there have been reports describing alterations in the pathological changes of the joint lesions with the use of these drugs. When one of our first cases to receive cortisone showed ...

Protein cleavage is a common feature in human neurodegenerative disease. Ataxin-3 protein with an expanded polyglutamine (polyQ) repeat causes spinocerebellar ataxia type-3 (SCA3), also called Machado-Joseph disease, and is cleaved in mammalian cells, transgenic mice and SCA3 patient brain tissue. However, the pathological significance of Ataxin-3 cleavage has not been carefully examined. To ga...

Effective vocal communication is critical in daily life, and 30% of the general population may suffer from a voice disorder at some point in their lives. Early diagnosis of voice pathologies facilitates mitigating symptoms and optimizing treatment for expedient recovery. Here, we studied the potential of an automated clinical decision support tool to differentiate subjects with early onset voic...

In the present paper a set of artificial intelligence methods are presented, with special focus on the pattern recognition algorithms and neural networks techniques, applied to the evaluation of deformed speech signal. The principal idea of the paper is the statement that in the presented problems the standard methods of signal processing and classification, widely applied for analysis and reco...

The ubiquitin-selective chaperone p97 is involved in major proteolytic pathways of eukaryotic cells and has been implicated in several human proteinopathies. Moreover, mutations in p97 cause the disorder inclusion body myopathy with Paget disease of bone and frontotemporal dementia (IBMPFD). The molecular basis underlying impaired degradation and pathological aggregation of ubiquitinated protei...

Pancreatic hemolymphangioma is a very rare benign tumor. There were only 10 reports of this disease until June 2014.The aim of the present study was to describe a hemolymphangioma in the neck and body of the pancreas in a 57-year-old woman.The method used in the present study consists of description of the clinical history, image lab features, and pathological result.The patient complained of a...