intervals of 1, 2 and 4 weeks between the sessions. The persistence of negative results of intradermal testing was confirmed before each desensitization procedure. Loss of skin sensitivity appeared to be a good predictor of tolerance of the drug. Both patients continued receiving cyanocobalamin injections monthly with good tolerance. Drug desensitization is time dependant and re-sensitization r...

BACKGROUND Novel immunosuppressive/modulating therapies with monoclonal antibodies (MABs) have been associated with progressive multifocal leukoencephalopathy (PML), a potentially fatal disease of the brain caused by the JC virus. Taking the complex diagnostic testing and heterogeneous clinical presentation of PML into account, an agreed case definition for PML is a prerequisite for a thorough ...

BACKGROUND In resource-poor settings, the provision of basic maternity care within health centres is often a challenge. Despite the difficulties, Nepal reduced its maternal mortality ratio by 80% from 850 to an estimated 170 per 100,000 live births between 1991 and 2011 to achieve Millennium Development Goal Five. One group that has been credited for this is community health workers, known as F...

Servicio de Dermatología, Hospital General Universitario de Valencia, Spain in 2004 and 2005.6 The highest number of positive reactions was seen with ketoprofen (45 cases). Promethazine occupied sixth place with 7 cases, although in none of them were the reactions considered relevant. In our experience, of the 48 photopatch tests done in the Dermatology Department of Hospital 12 de Octubre in M...

This phenomenon is the masking of endotoxin in undiluted materials, and is thought to be attributable to combinations of specific excipients. This differs from the inhibition or interference of endo toxin tests caused by pH, high divalent ion concentrations, chelators, serine proteases and beta­glucans, which can usually be overcome using a pre­treatment such as dilution. This guide provides an...

Antidepressant drug discovery and development have been put on hold by many pharmaceutical companies. The main reason for this is the negative efficacy studies with novel specific drugs. Here I argue that the main obstacles are the absence of gene tests and biomarkers as an integral part of a diagnostic process. Further, too much emphasis has been put on validating drug candidates in animal mod...

The reaction of the drug atenolol with hypochlorite under conditions that simulate wastewater disinfection was investigated. The pharmaceutical reacted in 1h yielding three products that were separated by chromatographic techniques and characterized by spectroscopic features. Two unusual products 2-(4-(3-(chloro(2-chloropropan-2-yl)amino)-2-hydroxypropoxy)phenyl) acetamide and 2-(4-(3-formamido...

The majority of newly-identified genes in the human genome show no significant sequence similarity to genes whose function is known, so they are not easily recognized as potential drug targets. Expression analysis is an alternative method to suggest possible functions of genes. We review statistical methods for gene expression analysis to identify potential pharmaceutical targets. Specifically,...