نتایج جستجو برای: pharmacogenomic

تعداد نتایج: 2060  

2017
Mehdi Najafzadeh Jorge A Garces Alejandra Maciel

BACKGROUND The response to therapeutics varies widely in patients with depression and anxiety, making selection of an optimal treatment choice challenging. IDgenetix®, a novel pharmacogenomic test, has been shown to improve outcomes by predicting the likelihood of response to different psychotherapeutic medications. OBJECTIVE The objective of this study was to estimate the cost effectiveness ...

2015
Felicia Stefania Falvella Marta Caporale Stefania Cheli Antonia Martinetti Rosa Berenato Claudia Maggi Monica Niger Francesca Ricchini Ilaria Bossi Maria Di Bartolomeo Elisa Sottotetti Francesca Futura Bernardi Filippo de Braud Emilio Clementi Filippo Pietrantonio

Fluoropyrimidines, the mainstay agents for the treatment of colorectal cancer, alone or as a part of combination therapies, cause severe adverse reactions in about 10%-30% of patients. Dihydropyrimidine dehydrogenase (DPD), a key enzyme in the catabolism of 5-fluorouracil, has been intensively investigated in relation to fluoropyrimidine toxicity, and several DPD gene (DPYD) polymorphisms are a...

Journal: :Clinical Pharmacology & Therapeutics 2013

Journal: :Proceedings for Annual Meeting of The Japanese Pharmacological Society 2018

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