This review evaluates the utilization of pharmacogenomic testing to guide treatment with antipsychotic medications as well as the evidence supporting the use of pharmacogenomic testing. There are two basic objectives for using pharmacogenomic testing. The first pharmacogenomic objective is to minimize adverse effects. The second pharmacogenomic objective is to improve clinical outcomes. While a...

BACKGROUND Pharmacogenomic clinical decision support systems (CDSS) have the potential to help overcome some of the barriers for translating pharmacogenomic knowledge into clinical routine. Before developing a prototype it is crucial for developers to know which pharmacogenomic CDSS features and user-system interactions have yet been developed, implemented and tested in previous pharmacogenomic...

BACKGROUND The use of pharmacogenomic testing in the clinical setting has the potential to improve the safety and effectiveness of drug therapy, yet studies have revealed that physicians lack knowledge about the topic of pharmacogenomics, and are not prepared to implement it in the clinical setting. This study further explores the pharmacogenomic knowledge deficit and educational resource needs...

More than 20 different pharmacogenomic tests are being used in the oncology field. The current descriptive study was conducted with 368 oncology nurses in North Carolina to identify and test key elements of Rogers' Diffusion of Innovation Theory that play a role in the adoption of pharmacogenomic testing. Oncology nurses who participated in this study had limited knowledge of genomics and pharm...

Genomic tests are the fastest growing sector in medicine and medical science, yet there remains a dearth of research on access to pharmacogenomic tests and medications. The objective of this study is to explore providers' and patients' experiences and views on test access as well as strategies used for gaining access. We interviewed clinicians who prescribed medications that should be guided by...

OBJECTIVES To explore the notion of mutation-centric pharmacogenomic relation extraction and to evaluate our approach against reference pharmacogenomic relations. METHODS From a corpus of MEDLINE abstracts relevant to genetic variation, we identify co-occurrences between drug mentions extracted using MetaMap and RxNorm, and genetic variants extracted by EMU. The recall of our approach is eval...

ObjectivesTo demonstrate the successful use of pharmacogenomic testing to specifically tailor antifungal treatment phenotype a patient with human immunodeficiency virus (HIV) and disseminated histoplasmosis who had clinical progression while on itraconazole subsequently insufficient therapeutic drug levels voriconazole.Case summaryWe present case HIV persistently elevated serum Histoplasma caps...

STUDY OBJECTIVES To review the labels of United States Food and Drug Administration (FDA)-approved drugs to identify those that contain pharmacogenomic biomarker information, and to collect prevalence information on the use of those drugs for which pharmacogenomic information is included in the drug labeling. DESIGN Retrospective analysis. DATA SOURCES The Physicians' Desk Reference Web sit...

Many clinical trials of oncology drugs now include at least a consideration of pharmacogenomics, the study of germline or acquired genetic factors governing a drug's response and toxicity. Besides the potential benefit to patients from the consideration of personalized pharmacogenomic information when making treatment decisions, the incentive is clear for oncology drug developers to incorporate...

Evidence of clinical utility is a key issue in translating pharmacogenomics into clinical practice. Appropriately designed randomized controlled trials generally provide the most robust evidence of the clinical utility, but often only data from a pharmacogenomic association study are available. This paper details a method for reframing the results of pharmacogenomic association studies in terms...