Two separation modes of capillary electrophoresis (CE): capillary zone electrophoresis (CZE) and micellar electrokinetic capillary chromatography (MECC) were used for toxicological analysis of blood samples and pharmaceutical preparations. These two techniques were tested on commonly used phenothiazines (PHE) and tricyclic antidepressants (TCA), which are drugs of forensic interest. The analyti...

A fatality due to ingestion of zolpidem, a recently developed nonbenzodiazepine hypnotic, and acepromazine, a phenothiazine sedative used in veterinary practice, is reported. Both drugs were identified and quantified using high-performance liquid chromatography with diode-array detection. Zolpidem and acepromazine blood concentrations were 3.29 and 2.40 micrograms/ml, respectively. It is the fi...

Specific binding of [3H]dopamine to membranes from the corpus striatum of rat and calf brain appears to involve the postsynaptic dopamine receptor. Specific [3H]dopamine binding is saturable, wnd with half-maximal binding in calf membranes at 7 nM. Apomorphine is about twice as potent as dopamine in competing for binding sites, whereas (-)norepinephrine is 5% as potent as dopamine and isoproter...

It is well known that hypoparathyroidism may present signs and symptoms of mental deficiency, neuroses or psychoses. Diverse neurological manifestations including extrapyramidal symptomatology have been noted as the only presenting signs in the absence of tetany (Fourman, et al; Kaye, et al; Greene and Swanson; Wise and Hart; Dimich, et al; Fonseca and Calverley; Sugar; Lachmann). Convulsions a...

The mechanisms of action of amphetamine and the antipsychotic drugs have been the subject of intense empirical and theoretical interest for a number of years. Amphetamine appears to act, in large measure, by promoting the release of catecholamines from central and peripheral ncrvc cndings and blocking their reuptake across the presynaptic membrane (1, 2). Antipsychotic drugs such as the phenoth...

In our previous work (Krizanová et al. 1989) we have described a protein from rabbit skeletal muscle cytosolic fraction, which is able to bind dihydropyridines and phenothiazines. In the present work conclusive evidence is provided for the ability of the phospholipid-reconstituted cytosolic protein to transport calcium. The calcium transport was stimulated by BAY K 8644 and inhibited in the pre...

A method is described to provide a rapid screening technique for the presence of barbiturates, glutethimide, carbromal, meprobamate, salicylate, phenothiazine derivatives, bromide, carbon monoxide, and alcohol. Phenothiazines are detected by a spot urine test. The first four drugs are identified, within 60 minutes of blood collection, on thin-layer chromatoplates of microscope slide dimensions....