Recognition of the molecular mechanisms of cAMP action against DNA damage-induced apoptosis can be useful to improve the efficacy of DNA damaging therapeutic agents. Considering the critical role of bcl-2-associated death promoter (BAD) and p53 proteins in DNA damage -induced apoptosis, the aim of this study was to assess the effect of cAMP-elevating agents on these proteins in doxorubicin-trea...

Abstract Transient receptor potential vanilloid 4 (TRPV4) plays an important role in chondrocytes via Ca 2+ signaling. However, its the progression of osteoarthritis is unclear. This study aimed to evaluate effects TRPV4 activation on articular cartilage and stimulated with interleukin (IL)-1?. Bovine human were various agents, including IL-1?, GSK1016790A (GSK101; a agonist), Compound C (an AM...

Propagation of tau fibrils correlate closely with neurodegeneration and memory deficits seen during the progression Alzheimer’s disease (AD). Although it is not well-established what drives or attenuates spreading, new studies on human brain using positron emission tomography (PET) have shed light how phosphorylation, genetic factors, initial epicenter accumulation influence propagation through...

Abstract Prefoldin is a heterohexameric complex conserved from archaea to humans that plays cochaperone role during the co-translational folding of actin and tubulin monomers. Additional functions prefoldin have been described, including positive contribution transcription elongation chromatin dynamics in yeast. Here we show perturbations provoked transcriptional alterations across human genome...

One of the main mechanisms regulating translation is one based on phosphorylation alpha subunit initiation factor 2 (eIF2α) by general control non-repressive (GCN2) protein kinase. In yeast, this kinase binds to two scaffold proteins (GCN1 and GCN20), facilitating its activation translating ribosomes. The homology three exists in Arabidopsis. species, whereas activated under several stress situ...

Quorum sensing is being investigated as an alternative therapeutic strategy in antibacterial drug discovery programs aimed at combatting bacterial resistance. LsrK autoinducer-2 kinase (belongs to the sugar family), playing a key role phosphorylation of (AI-2) signaling molecules involved quorum sensing. Inhibiting could result reduced pathogenicity by interfering with signaling. Previously, we...

Significance Mutations that activate LRRK2 protein kinase cause Parkinson's disease. phosphorylates a subset of Rab GTPases, in particular Rab8 and Rab10. We show here details related to the mechanism by which Rab10 phosphorylation blocks initiation cilia formation, fundamental information how pathogenic interferes with normal cell physiology.

Abstract Ceramide kinase (CERK) phosphorylates ceramide to produce ceramide-1-phosphate (C1P), which is involved in the development of metabolic inflammation. TNF-? modulates inflammatory responses monocytes associated with various disorders; however, underlying mechanisms remain not fully understood. Here, we investigated role CERK TNF-?-induced monocytes. Our results show that disruption acti...