Introduction. Triple-negative breast cancer (TNBC) is characterized by a lack of oestrogen, progesterone and human epidermal growth factor receptors. It the one most heterogeneous highly-aggressive cancers, resulting in fast progression. In humans, lymphocyte activation gene 3 ( LAG3 ) located on chromosome 12p13 encodes an immune-regulatory molecule. The aim study was to perform molecular anal...

The distribution of factor V Leiden G1691A, II G20210A, MTHFR C677T, and H1299R polymorphisms known to predispose thrombophilia in 215 cases 40 controls admitted with indication recurrent pregnancy loss (RPL) was investigated. Genotyping performed by melting curve analysis using simultaneous PCR (RT-PCR). There no difference between genotype allele frequencies the case control groups terms exam...

objective: in peripheral blood polymorphonuclear and mononuclear cells nitric oxide (no) could be synthesized by an enzyme called inducible no synthase (inos). inos gene (nos2a) is located on chromosome 17 at position 17q11.2-q12. no is released during inflammatory responses. in the present studies the frequency of nos2a gene polymorphisms and their effects on no production were investigated in...

conclusions this study supports the idea that the ifnl3 gene is an important predictor of the response of chb patients to ifn therapy. results nine studies of 1602 chb patients receiving ifn treatment were included. under the random-effects model, patients expressing the variant rs12980275 showed a significantly increased response to ifn therapy (or = 2.85; 95% ci = 1.14 - 4.60). in the subgrou...

estrogen might play an important role in the pathogenesis of diabetes mellitus type 2. estrogens inhibit diabetes via distinct mechanisms particularly by reducing both hyperglycemia and plasma insulin levels. estrogen exerts its physiological effects mainly through estrogen receptors including α and β types. estrogen receptors are found in many tissues that participate in the pathogenesis of ty...

Hypertension has relatively large morbidity and mortality rates throughout the world, including in Indonesia. The prevalence of hypertension tends to be greater patients with a family history hypertension. This is thought influenced by polymorphisms

objectives analysis of ns5a polymorphisms in hcv genotype 1b pre-treatment serum samples from estonian patients and their effect on the treatment response. patients and methods twenty-nine complete ns5a sequences obtained from patients with chronic hcv-1b infection who had received combined therapy with pegifnα-2a/rbv were analyzed and compared with the prototype strain hcv-j. twelve patients a...

background: some dynamic changes occurs during spermatogenesis such as histone removal and its replacement with transition nuclear protein and protamine. these proteins are required for packing and condensation of sperm chromatin. jhdm2a is a histone demethylase that directly binds to promoter regions of tnp1 and prm1 genes and controls their expression by removing h3k9 at their promoters.objec...

abstract objectives: tumour necrosis factor α (tnfα) and lymphotoxin α (ltα) have been implicated in the pathogenesis of lymphoproliferative disorders. patients with b-cell non-hodgkin’s lymphoma (nhl) often have high serum levels of tnf which may be associated with a poor outcome. tnfα and ltα polymorphisms are known to influence expression of these cytokines and may explain the variable respo...