The health effects of asbestos have become a cause of serious concern in recent years. It has been estimated that from 1940 to 1979, in the United States alone, 27,500,000 individuals were exposed to this mineral at work. Recognition of the diseases caused by asbestos exposure has led manufacturers to reduce exposure in a variety of ways, such as by using alternative materials and by institutin...

BACKGROUND To examine the effect of gastrin on spontaneous and induced pancreatic carcinogenesis in the hamster. METHODS AND RESULTS Two sets of experiments were carried out, one involving long term hypergastrinaemia and one involving cancer induction during hypergastrinaemia. The effect of hypergastrinaemia accomplished by gastric fundectomy was studied for eight months. Neither fundectomise...

OBJECTIVE: to assess the cervical cancer screening tests in Teresina, Piauí, Brazil. METHODS: this is an evaluation study of Teresina Cervical Cancer Information System (Siscolo), for the period from 2006 to 2013, based on descriptive statistical analyses. RESULTS: 604,331 pap smear tests of women residents in Teresina were registered on the system; 1.8% presented premalignant or malignant ...

In a previous investigation (Larsson and Lorentzon 1974) on the geographical variation of the incidence of malignant primary bone tumours, osteogenic sarcoma, chondrosarcoma and Ewing’s sarcoma were found to show a striking similarity in the pattern of variation of the factors studied. Thus, all three tumours showed a significantly higher incidence in the southern part of Sweden than in the res...

Development of imaging agents that can be used broadly for early detection of neoplasia at various tissue sites and at various stages of disease and that also can assess states of minimal residual disease would have tremendous utility in the diagnosis and management of cancer. In a series of articles culminating with a report in this issue of the journal (beginning on page 1536), Uddin and coll...

Background Hu-antigen R (HuR) is a posttranscriptional regulator of several target mRNAs, implicated in carcinogenesis. This review aims to present the current evidence regarding the biological role and potential clinical significance of HuR in head and neck carcinomas. Methods The existing literature concerning HuR expression and function in head and neck carcinomas is critically presented a...

H-2K/v-jun transgenic mice develop sarcomas at sites of wounding via a multistep process characterized by discrete pathological stages. To study this progression in vitro, cells from different stages of tumorigenesis were cultured and examined for their growth properties. The results show that whereas transgenic fibroblasts do not manifest enhanced proliferative potential in vivo in the absence...

Oral dysplastic lesions may have an increased chance of becoming oral squamous cell carcinoma, but to date their management remains controversial. The aim of this survey was to explore the current practical aspects of the management of patients with dysplasia by oral and maxillofacial consultants in the UK. In the survey we asked consultants about the numbers of patients they see with oral prem...

BACKGROUND AND AIMS To assess the expression levels of cathepsins in malignant and premalignant lesions. METHODS We retrospectively included patients who underwent pancreatic surgery on pancreatic solid or cystic masses. The expression of cathepsin H, L, B and S was determined in both types of samples. Lesions were divided into three categories: malignant (pancreatic adenocarcinoma and malign...

Oral submucous fibrosis (OSF) is now accepted globally as an Indian disease, having highest malignant potential than any other oral premalignant lesions. The understanding of the exact role of alkaloids and other etiological agents with respect to pathogenesis will help the management and minimize the blind clinical trials and treatment modalities. This article provides an overview of the etiop...