cancer of the oral cavity accounts for approximately 3% of all malignancies diagnosed annually in 270,000 patients worldwide. oral cancer is the 12th most common cancer in women and the 6th in men. many oral squamous cell carcinomas develop from potentially malignant disorders (pmds). lack of awareness about the signs and symptoms of oral pmds in the general population and even healthcare provi...

of Ph. D. Thesis

it has been argued that oral lichen planus (olp) may increase the risk of oral cancer. patients with olp may be at an increased risk for developing of oscc (oral squamous cell carcinoma). here, the author reports a case of olp initially presenting with a clearly benign olp lesion that transformed into oscc over a course of 18 months. this report may provide a clear evidence for olp lesion as a ...

The evidence appears compelling that the microenvironment, and associated biological cellular and molecular factors, may contribute to the progression of a variety of tumors. The effects of the microenvironment may directly influence the plasticity of T cell lineages, which was recently discussed (O'Shea & Paul, 2010 [4]). To review the putative role of the microenvironment in modulating the co...

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BACKGROUND Symptoms other than pain are a heavy burden for patients with either malignant or progressive nonmalignant disease and significantly reduce quality of life. OBJECTIVE This article discusses the management of symptoms of malignant or progressive nonmalignant disease in the general practice setting. DISCUSSION The approach to management of the symptoms of malignant or progressive n...

The method of alkaline elution was used to detect DNA alteration in rat liver throughout the carcinogenic sequence that resulted from exposure to a standard four-cycle feeding regimen of 2-acetylaminofluorene (AFF). At the end of 3 weeks of AAF feeding, DNA from aliquots of whole liver demonstrated a small but significant degree of damage. By the end of the fourth AAF feeding, the liver exhibit...