1-[4-(2-Alkylaminoethoxy)phenylcarbonyl]-3,5-bis(arylidene)-4-piperidones are a novel class of potent cytotoxic agents. These compounds demonstrate low micromolar to submicromolar IC50 values against human Molt 4/C8 and CEM T-lymphocytes and murine leukemia L1210 cells. In this study, a comparative QSAR investigation was performed on a series of 3,5-bis(arylidene)-4-piperidones using different ...

OBJECTIVE To update previous systematic review of predictive models for 28-day or 30-day unplanned hospital readmissions. DESIGN Systematic review. SETTING/DATA SOURCE CINAHL, Embase, MEDLINE from 2011 to 2015. PARTICIPANTS All studies of 28-day and 30-day readmission predictive model. OUTCOME MEASURES Characteristics of the included studies, performance of the identified predictive mod...

A simulation study was conducted to address the issue of how purely additive (simple) genetic architecture might impact on the efficacy of parametric and non-parametric genomic prediction methods. For this purpose, we simulated a trait with narrow sense heritability h2= 0.3, with only additive genetic effects for 300 loci in order to compare the predictive ability of 14 more practically used ge...

the purpose of this study is to provide a model for performance evaluation of sepah bank branches by using partial indicators through combining controllable and uncontrollable potential variables with performance variables. with description and expansion of performance concepts of branches, a complete list of pre-test variables, including forty nine potential variables and five performance vari...

We analyze how different dimensions of a seller’s reputation affect pricing power in electronic markets. We do so by using text mining techniques to identify and structure dimensions of importance from feedback posted on reputation systems, by aggregating and scoring these dimensions based on the sentiment they contain, and using them to estimate a series of econometric models associating reput...

In the sparse linear regression setting, we consider testing the significance of the predictor variable that enters the current lasso model, in the sequence of models visited along the lasso solution path. We propose a simple test statistic based on lasso fitted values, called the covariance test statistic, and show that when the true model is linear, this statistic has an Exp(1) asymptotic dis...

Predictive modeling is the process of creating a statistical model from data with the purpose of predicting future behavior. In recent years, the amount of available data has increased exponentially and “Big Data Analysis” is expected to be at the core of most future innovations. Due to the rapid development in the field of data analysis, there is still a lack of consensus on how one should app...