The local anesthetic activities of 1-(morpholino or piperidino)-2-propanol derivatives were investigated. These activities were observed with nerve trunk anesthesia, rabbit's corneal anesthesia and intradermal injection anesthesia. Among these propanol derivatives, No. 24 and No. 25 which possess thioether-type sulfur were the most active and the effective potency was enhanced by increasing the...

I toxic epidermal necrolysis (TEN), a wide layer of skin is peeled and an immature skin layer appears. In a short period, an epidermal necrolysis characterized by scalded appearance of skin due to febrile toxic reaction develops. The mortality rate of this disease is high (20-70%), due to dramatic drug reactions of the skin. The disease resembles mostly to erythema multiforme (EM), Steven Johns...

the effect of 10 and 25 kgy ?-irradiation on penicillin g plus procaine and sodium ampicillin has been assessed by different chemical and microbiological analytical methods. according to the chemical results obtained, the antibiotics showed a slight reduction in doses applied but the microbiological assays revealed that the activity of irradiated antibiotics did not reduce. microbiological stud...