background:   objective: the purpose of this study was to compare the predictive value of progesterone level on ivf success in women with infertility due to tubal factor or pcos.   materials and methods: in a stratified cohort study, we assigned 76 infertile women of 20-38 years old who referred to women hospital into two equal groups with fallopian tube factor infertility and pcos. we measured...

background: the purpose of the study was to evaluate the role of progesterone/ estradiol (p4/e2) ratio as a predictive tool for clinical pregnancy in art cycles with a premature progesterone rise of >1.5 ng/ml on the day of human chorionic gonadotropin (hcg) trigger. methods: retrospective analysis was done on 569 fresh embryo transfer cycles from january 2011 to december 2012 at the infertilit...

objective: although much is known about estrogen and progesterone, their toxicity or protective effects on hepatocytes are yet to be fully understood. this study investigated the probable oxidant or antioxidant effects of estrogen and progesterone on hepg2 cell line in the presence or absence of h2o2. methods: hepg2 cells were cultured with two concentrations of estrogen and progesterone (10pm ...

conclusions in summary, progesterone administration reduced serum icam-1, and whereby may attenuate blood brain barrier disruption, the latter needs further investigation for confirmation. results a reduction in the serum level of icam-1 was noticed in the progesterone group 24 hours after the injury (p < 0.05). there was no significant difference in the serum level of nse between the study gro...

OBJECTIVES The purpose of this study was to characterize clopidogrel hypersensitivity and describe its successful management with oral steroids without clopidogrel discontinuation. BACKGROUND Hypersensitivity reactions to clopidogrel are poorly understood and present difficulty in management. METHODS Patients diagnosed with clopidogrel hypersensitivity after percutaneous coronary interventi...

The causes of imminent abortion are multi-factorial. The biggest causal factor is the low level of serum progesterone level. The lowest critical level of serum progesterone for survivability of pregnancy is 10 ng/ml. Eighty percent of patients experiencing abortion showed that their progesterone level was < 10 ng/ml. Patients who realized that their pregnancy would experience hemorrhage general...

The prospect of biomaterial hypersensitivity developing in response to joint implant materials was first presented more than 30 years ago. Many studies have established probable causation between first-generation metal-on-metal hip implants and hypersensitivity reactions. In a limited patient population, implant failure may ultimately be related to metal hypersensitivity. The examination of hyp...

Skin hypersensitivity to streptococcal antigens was demonstrated in 15 New Zealand red rabbits that were sensitized by intracutaneous injections with group A streptococci, and leukocytic hypersensitivity, as determined by in vitro inhibition of leukocyte migration, was demonstrated in 11 of the rabbits. The skin hypersensitivity persisted for at least 8 weeks, whereas the leukocytic hypersensit...

With its genomic and non-genomic actions, progesterone plays a role in preparing the endometrium for implantation and also in regulating trophoblast invasion and migration. The genomic actions of progesterone are mediated by the classical nuclear progesterone receptors, PR-A and PR-B. In addition to their genomic actions, nuclear progesterone receptors may also trigger rapid cytoplasmic signall...

The ovarian steroid hormone, progesterone, and its nuclear receptor, the progesterone receptor, are implicated in the progression of breast cancer. Clinical trial data on the effects of hormone replacement therapy underscore the importance of understanding how progestins influence breast cancer growth. The progesterone receptor regulation of distinct target genes is mediated by complex interact...