نتایج جستجو برای: progressive supranuclear pal
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We would like to reply Yang et al., 2020, reporting a patient diagnosed with progressive supranuclear palsy (PSP) who carried two novel heterozygous missense variants in GRN gene. The case reported by raises some concerns. In summary, the study of reports PSP-like phenotype patients carrying gene, putatively compound heterozygous. Finally, we suggest that further analyses (including segregation...
BACKGROUND Parkinson disease (PD) is characterized by loss of dopaminergic neurons in the substantia nigra. Genes contributing to rare mendelian forms of PD have been identified, but the genes involved in the more common idiopathic PD are not well understood. OBJECTIVES To identify genes important to PD pathogenesis using microarrays and to investigate their potential to aid in diagnosing par...
INTRODUCTION Qing fei tang, which is used for various respiratory diseases, is useful for reducing relapse of aspiration pneumonia and bronchopneumonia in stroke, but the effect remains unknown in Parkinson's syndrome. We report two cases of Japanese patients with progressive supranuclear palsy and relapsing aspiration pneumonia and bronchopneumonia, which was successfully prevented by qing fei...
Impaired transduction of transforming growth factor-A signaling has recently been implicated in Alzheimer disease. Transforming growth factor-A signals are transduced by Smads, which are phosphorylated and translocated to the nucleus, where they initiate gene transcription. In Alzheimer disease, neurofibrillary tangles sequester phosphorylated Smad 2/3 (pSmad2/3) and reduce its nuclear transloc...
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