OBJECTIVE To evaluate the effects of pentoxifylline on hydrochloric acid-induced lung lesions in rats subjected to mechanical ventilation. METHODS Twenty male, adult Wistar-EPM-1 rats were anesthetized and randomly grouped (n=5 animals per group) as follows: control-MV (mechanical ventilation, MV group); bilateral instillation of HCl (HCl group); bilateral instillation of HCl followed by pent...

Abstract Background Oncolytic viruses (OVs) are considered a promising therapeutic alternative for cancer. However, OVs could activate the host innate immunity, then impair viral propagation in tumor cells. In this study, we explored effect of propranolol, non-selective β-blocker, on antitumor efficacy T1012G virus gastric cancer models. Methods The proliferation cells treated with monotherapy ...

the β2-adrenergic effects of macerated extract, aqueous extract, ethanol extract, and essential oil of carum copticum, 5 nm propranolol, and saline were tested by performing cumulative log concentration-response curves of isoprenaline-induced relaxation of precontracted isolated guinea pig tracheal chains in three different conditions including: non-incubated (group 1, n=9) incubated with 1 µm ...

Background: Akathisia is a common adverse effect of antipsychotic drugs and is characterized by subjective feelings of restlessness. First-line treatment usually consists of propranolol, a beta adrenergic antagonist. However, propranolol does not seem to be efficacious in up to 70% of patients. This study was aimed to evaluate the effect of vitamin B6 versus propranolol on antipsychotic-induced...

the forced degradation study of lidocaine hcl was carried out according to the ich guideline q1a (r2). the degradation conditions were assessed to be hydrolysis, oxidation, photolysis and dry heat during 24 h, 48 h and 72 h and then the samples were investigated by gc-fid method and nuclear magnetic resonance (nmr) spectroscopy. according to these results, the degradation products were not obse...

nolol is essentially complete, and no metabolism of this drug occurs in the gut. After the oral administration of propranolol, the liver is the principal site of extensive pre-systemic and systemic metabolism, and less than 1% of the intact drug is found in the urine. However, Bianchetti et al. showed that the area under the concentration–time curve for orally administered propranolol in renal ...

1. In Expt I, a pelleted grass-meal diet was supplemented with hydrochloric acid, added to the grass pellets before feeding, at five levels from 0 to 628 mmol/kg dry matter (DM). Each diet was offered ad lib. for 21 d to five sheep in a 5 x 5 Latin-square design. 2. Voluntary food intake decreased rectilinearly with increasing HCl supplementation (P less than 0.001), to 42% of the control value...

a one-pot synthesis of (s)-(-)-propranolol is reported. zn(no3)2/(+)-tartaric acid catalyzed enantioselective synthesis of (s)-(-)-propranolol via kinetic resolution of key intermediate ?-naphthyl glycidyl ether with high optical and chemical yield.

background hemangiomas, usually, present at the first few hemangiomas, usually, present at the first few months of life and are the most common benign tumor in children. there are various therapeutic methods for hemangioma. capillary hemangioma is a type of hemangiomas. the steps of treatment of a child with capillary hemangioma in taleghani hospital of gorgan, iran, are reported. case report i...

Krag, Aleksander, Lene Simonsen, Jens H. Henriksen, Lone Ottesen, and Flemming Bendtsen. Effect of meal and propranolol on whole body and splanchnic oxygen consumption in patients with cirrhosis. Am J Physiol Gastrointest Liver Physiol 291: G8–G15, 2006. First published February 23, 2006; doi:10.1152/ajpgi.00315.2005.—Our aim was to measure whole body energy expenditure after a mixed liquid mea...