Abstract Background Clinical applications of RNA interference for cancer treatment and immune therapy require the development simultaneous imaging systems microRNA. This research was performed to fabricate miRNA34a-loaded magnetic nanoparticles investigate its anticancer effects against triple-negative breast (TNBC) in mice model. Results Using two types polymers improve their water dispersibil...

Protein-protein interactions have been widely used to study gene expression pathways and may be considered as a new approach to drug discovery. Here I report the development of a universal protein array (UPA) system that provides a sensitive, quantitative, multi-purpose, effective and easy technology to determine not only specific protein-protein interactions, but also specific interactions of ...

topical and transdermal drug delivery systems are noninvasive and can be self-administered with the minimization of side-effects, have received increased attention during the past few years. nanoemulsions, emulsions sized between 20-200 nm with narrow distributions, offer several advantages for topical and transdermal delivery of pharmaceutical agents including controlled droplet size, the abil...

The pharmaceutical area can present some opportunities for mechanical engineers to develop a vast type of dosage forms particularly novel forms like nanoparticles. The classical education of mechanics needs some alterations to prepare appropriate education courses in this regard. In order to present some views about this issue, we collect some information around the importance of mechanical eng...

Targeted Protein Deliveries In article number 2204620, Hak-Sung Kim and co-workers develop a new type of protein self-assembly using human clathrin for targeted delivery. A redesigned triskelion is dual-functionalized with functional biomolecules. The resulting assembly exhibits significantly high avidity an efficient delivery cargo into tumor cells.

Injectable controlled-release systems based on biodegradable copolymers of lactic and glycolic acids (PLGAs) have become widely used for delivery of protein therapeutics and vaccine antigens. Over the last five years, great strides have been made toward overcoming the difficulty of stabilizing PLGA-encapsulated proteins. In addition to stabilizing proteins during encapsulation with anhydrous me...

Polymeric delivery systems have been extensively studied to achieve localized and controlled release of protein drugs. However, it is still challenging to control the release of multiple protein drugs in distinct stages according to the progress of disease or treatment. This study successfully demonstrates that multiple protein drugs can be released from aptamer-functionalized hydrogels with ad...

Stephen Perrett is currently the Corporate Technology Director at Eurand. He is responsible for Merger and Acquisition activities and for the licensing in of new technologies for the Eurand Group. Through internal development and acquisition Eurand now controls one of the broadest ranges of drug delivery technologies in the industry. Dr Perrett has 20 years of experience in the drug delivery in...