High dose intravenous(i.v.) ascorbic acid (AA) has been used as therapy for infectious disease from bacterial and viral origin and adjuvant therapy for cancer. In this publication we describe a clinical protocol that has been developed over the past twenty years utilizing high dose i.v. AA as therapy for cancer. This includes principles of treatment, rationale, baseline workup, infusion protoco...

Vulvodynia, an idiopathic chronic vulvar pain, is a prevalent genital pain condition that results in significant impairment to sexual, relational, and psychological functioning of affected women and their romantic partners. Despite its high prevalence, there remain gaps in knowledge and health care access for women coping with vulvodynia, given its varied clinical presentation and no widely acc...

Mastoid subperiosteal abscess (SA) is the most common complication of acute mastoiditis. Today, no uniformly accepted diagnostic or treatment protocols exist. Imaging studies for all patients and mastoidectomy plus myringotomy, traditionally constitute the gold-standard of treatment methods. However, more conservative approaches viewed as safe and reliable alternative options for the clinician ...

This review aimed to ascertain the extent to which nonadherence to treatment protocol is reported and addressed in a cohort of published analyses of randomised controlled trials (RCTs). One hundred publications of RCTs, randomly selected from those published in BMJ, New England Journal of Medicine, the Journal of the American Medical Association and The Lancet during 2008, were reviewed to dete...

BACKGROUND A retrospective study of rabbits treated against cheyletiellosis was performed to evaluate the efficacy and safety of selamectin or ivermectin in clinical practice. METHODS Medical records from 53 rabbits with microscopically confirmed Cheyletiella infestation were collected from two small animal clinics. The rabbits were divided into three groups, based on treatment protocols. Gro...

OBJECTIVE To assess mature burn scars treated with a fractional carbon dioxide laser for changes in histological architecture, type I to III collagen ratios, density of elastic tissue, and subjective measures of clinical improvements. DESIGN Uncontrolled, prospective study of patients with mature burn scars, from a clinical and histological perspective. Biopsy specimens were obtained before a...

Many negotiate their way through and make sensible choices, but my oncology colleagues and I continue to see patients who choose extreme dietary and alternative treatments for potentially curable cancers and don’t turn to us until they are quite ill and their cancer has spread and become incurable. To see patients with early disease, who would have an excellent prognosis if standard treatment p...

WHAT DID THE AUTHORS STUDY? In their study, “Dexamethasone and long-term survival in bacterial meningitis,” Dr. Fritz and his colleagues carefully evaluated 2 ways to treat bacterial meningitis. They compared steroids (dexamethasone) with placebo. The doctors gave medication (or placebo) in addition to antibiotics, the usual treatment for bacteria. In other words, Dr. Fritz et al. compared anti...

The Internet has enabled online social interaction for scientists that previously happened only in physical meetings and conferences. Yet despite these innovations in communication, dissemination of methods is often relegated to the slow process of academic publishing. Further, these methods remain static, with subsequent advances published elsewhere and unlinked. For communities undergoing fas...