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تعداد نتایج: 221618 فیلتر نتایج به سال:
Huntington's disease (HD) is a fatal neurodegenerative condition caused by expansion of the polyglutamine tract in the huntingtin (Htt) protein. Neuronal toxicity in HD is thought to be, at least in part, a consequence of protein interactions involving mutant Htt. We therefore hypothesized that genetic modifiers of HD neurodegeneration should be enriched among Htt protein interactors. To test t...
Leakage power has become a serious concern in nano meter CMOS technologies, and power-gating has shown to offer a viable solution to the problem with a small penalty in performance. This paper focuses on leakage power reduction through automatic insertion of sleep transistors for power-gating. In particular, we propose a novel, layout-aware methodology that facilitates sleep transistor insertio...
Spliceosomes are multimegadalton RNA-protein complexes responsible for the faithful removal of noncoding segments (introns) from pre-messenger RNAs (pre-mRNAs), a process critical for the maturation of eukaryotic mRNAs for subsequent translation by the ribosome. Both the spliceosome and ribosome, as well as many other RNA and DNA processing machineries, contain central RNA components that endow...
Alpha-synuclein (α-SYN) is a central molecule in Parkinson’s disease pathogenesis. Despite several studies, the molecular nature of endogenous α-SYN especially in human brain samples is still not well understood due to the lack of reliable methods and the limited amount of bio-specimens. Here, we introduce α-SYN single-molecule pull-down (α-SYN SiMPull) assay combined with in vivo protein cross...
Recent development of methods for genome-wide identification of transcription factor binding sites by chromatin immunoprecipitation (ChIP) has led to novel insights into transcriptional regulation and greater understanding of the function of individual transcription factors. ChIP requires highly specific antibody against the transcriptional regulator of interest, and availability of suitable an...
New exciting experimental approaches to transcriptome-wide identification of microRNA binding sites are revealing surprising details about microRNA interaction with RNA targets. Approximately one out of five microRNA interactions occur without canonical perfect base pairing to the seed sequence. Instead they are often governed by imperfect binding to the center of the microRNA. One primate spec...
When the input signal has been interfered and glitches occur, power consumption of Double-Edge Triggered Flip-Flops (DETFFs) will significantly increase. To effectively reduce consumption, this paper presents an anti-interference low-power DETFF based on C-elements. The improved C-element is used in DETFF, which blocks signal, prevents redundant transitions inside reduces charge discharge frequ...
Tab2, originally described as a component of the inflammatory pathway, has been implicated in phenomena of gene de-repression in several contexts, due to its ability to interact with the NCoR corepressor. Tab2 interacts also with steroid receptors and dismisses NCoR from antagonist-bound Estrogen and Androgen Receptors on gene regulatory regions, thus modifying their transcriptional activity an...
The allocation of inventory ownership affects the inventory availability in a supply chain, which in turn determines the supply chain performance. In this paper, we consider a supplier-retailer supply chain in which the supplier starts production well in advance of the selling season, and the retailer is offered two ordering opportunities at different points in time. An early order is allowed b...
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