The t(3;21)(q26.2;q22) translocation is a rare chromosomal abnormality exhibited almost exclusively in therapy-related myelodysplastic syndrome/acute myeloid leukemia (t-MDS/AML) or in the blastic crisis phase of chronic myelogenous leukemia, which results in the fusion of the runt related transcription factor 1 (RUNX1, also called AML1) gene at 21q22 to the myelodysplasia syndrome 1 (MDS1)-eco...

Complex small supernumerary marker chromosomes (sSMCs) constitute one of the smallest subsets within the patients with an sSMC. Complex sSMCs consist of chromosomal material derived from more than one chromosome, for example, the derivative der(22)t(11;22)(q23;q11.2) in Emanuel syndrome. Here, a yet unreported case of a complex sSMC formed due to a t(7;9)(p22;q22)mat is presented.

n recent years several leukemia-specific cyto-genetic abnormalities have been identified and the related molecular lesions characterized. 1 These include, among others: t(15;17) (q23;q21) with PML/RAR␣ fusion gene; t(8;21) (q22;q22) with AML1/ETO chimeric gene; inv(16) with CBFb/MYH11 hybrid gene; 11q23 translocations with MLL gene lesions, and t(5;9)(q21;q28) with DEK/CAN chimeric gene. Studie...

In high-enthalpy air flows, nitric oxide (NO) formation and removal involves multiple, complex energy transfer processes that occur under nonequilibrium conditions, thus motivating the need for diagnostic methods to probe such flows in laboratory settings. this work, a rotational temperature NO was developed using spectroscopic model (Stanford model) of γ-bands inform optimal wavelength candida...

Leiomyoma of deep soft tissue is a rare type of benign smooth muscle tumor that mostly occurs in the retroperitoneum or abdominal cavity of women, and about which very little genetic information exists. In the present study, eight leiomyomas of deep soft tissue were genetically analyzed. G-banding showed that three tumors carried rearrangements of the long arm of chromosome 12, three others had...