Serratia marcescens is an important opportunistic pathogen in hospitals, where quaternary ammonium compounds are often used for disinfection. The aim of this study is to elucidate the effect of a biocide on the emergence of biocide- and antibiotic-resistant mutants and to characterize the molecular mechanism of biocide resistance in Serratia marcescens. A quaternary ammonium compound-resistant ...

Bifunctional chiral urea-containing quaternary ammonium salts can be straightforwardly synthesised in good yield and with high structural diversity via a scalable and operationally simple highly telescoped sequence starting from trans-1,2-cyclohexanediamine. These novel hybrid catalysts were systematically investigated for their potential to control glycine Schiff bases in asymmetric addition r...

conclusions bacterial resistance against quaternary ammonium compounds is increasing which can increase the bacterial biofilm formation. results the means of strains growth increase after the minimal inhibitory concentration (mic) were significant in all the bacteria (except for e. coli in 1/32 and s. agalactiae in of 1/8 mic). biofilm formation increased with decrease of antiseptics concentrat...

Vol. 176, No. Printed in (I.S.A ASGHAR. KHURSHEED AND LLOYD J. Ro’rH: Distribution of hexamethonium and other (luaternary anhIlloIliufli compounds in (alt ilage. .J. Pliarmacol. Ex1). Ther. 176: 83-92. 1971. N-methyl-C’4and H3-labeled hexamethonium was administered to rats and mice in a dose of 10 to 30 mg/kg. Tissue sections for whole body and cellular autoradiography were cut from animals sac...

The antibacterial activity of alanine-derived gemini quaternary ammonium salts (chlorides and bromides) with various spacer and alkyl chain lengths was investigated. The studied compounds exhibited a strong bactericidal effect, especially bromides with 10 and 12 carbon alkyl chains and 3 carbon spacer groups (TMPAL-10 Br and TMPAL-12 Br), with a short contact time. Both salts dislodged biofilms...