Our meta-analysis analyzed the relationship between levels of reactive oxygen species (ROS) and fertilization rate after in vitro fertilization (IVF), and showed a statistically significant correlation between the ROS levels and the IVF fertilization rate (estimated overall correlation -0.374 [95% CI, -0.520, -0.205]). We conclude that ROS has a statistically significant effect on the fertiliza...

Clearance of senescent cells from damaged tissue is a crucial step to successfully resolve an inflammatory response. Poor clearance has been attributed to defects in neutrophil apoptosis, a process that is regulated in part by reactive oxygen species (ROS) produced by activated neutrophils. Using ROS-deficient and wild-type macrophages treated with extracellular ROS scavengers we demonstrate th...

Abstract Reactive oxygen species (ROS) are not only toxic agents but also potent signaling molecules. NADPH oxidases the sole enzymes to generate ROS playing an important role in redox signaling. They closely interact several ways with hypoxia-inducible transcription factors of HIF family. This network is active under normoxic and hypoxic conditions as regulator homeostasis. Members oxidases-HI...

Upon light irradiation, a novel dual-functional ruthenium compound releases nitric oxide (NO) and reactive oxygen species (ROS). NO induces Pseudomonas aeruginosa biofilm dispersal liberates bacteria. The free-floating bacteria are subsequently sterilized by ROS. Therefore, the can readily eradicate mature biofilms at low concentration, which reduces cytotoxicity to mammalian cells. More inform...

Oxidative stress has been proposed to be one of the main causes of aging and has been implicated in the pathogenesis of many diseases. Sensitivity to oxidative stress can be measured by quantifying survival following exposure to a reactive oxygen species (ROS)-generating compound such as paraquat or juglone. Sensitivity to oxidative stress is a balance between basal levels of ROS, the ability t...

Our understanding of the role of oxygen in cell physiology has evolved from its long-recognized importance as an essential factor in oxidative metabolism to its recognition as an important player in cell signaling. With regard to the latter, oxygen is needed for the generation of reactive oxygen species (ROS), which regulate a number of different cellular functions including differentiation, pr...

It is one of the paradoxes of biology that oxygen, which is required for energy production in aerobic organisms, is also very toxic. Many biological reactions generate reactive oxygen species (ROS) that strip electrons from biological molecules such as fatty acids, proteins and DNA. Exposure of cells to ROS can lead to disruptions in membrane structure, reduced activity of enzymes and other pro...