«replication»
۱۷۳٬۰۲۵ نتیجهORChestrating the human DNA replication program.
In humans, more than 6 billion bp of DNA need to be copied accurately and completely every cell division. Given the size of human chromosomes, it would take a pair of bidirectional DNA replication forks, emanating from a single replication origin, more than 40 days to copy just c
Rif1 choreographs DNA replication timing.
Eukaryotic cells duplicate their genome in a predetermined order that appears to reflect a fundamental property of chromatin. Each chromosomal region replicates at a consistent, developmentaland tissue-specific time during the S phase of the cell cycle, and regions that replicate
DNA replication: one strand may be more equal.
Living organisms are highly organized adaptive systems. Whereas the maintenance of organization requires conservation, adaptation requires variation. Evolution, the fundamental strategy of Life, is an interplay of genetic variation and phenotypic selection. The wide variety of sp
Replication protein A binds to regmlatory elements in yeast DNA repair and DNA metabolism
Saccharomyces cerevisiae responds to DNA damage by arresting cell cycle progression (thereby preventing the replication and segregation of damaged chromosomes) and by inducing the expression of numerous genes, some of which are involved in DNA repair, DNA replication, and DNA met
Molecular and Cellular Pathobiology Human Nuclease/Helicase DNA2 Alleviates Replication Stress by Promoting DNA End Resection
In precancerous and cancerous lesions, excessive growth signals resulting from activation of oncogenes or loss of tumor suppressor genes lead to intensive replication stress, which is recognized by a high level of replicationassociated DNA double-strand breaks (DSB). However, the
Epstein-Barr Virus DNA Replication
Epstein-Barr virus (EBV) and its close relatives are the only known viruses that have two fully independent systems for replicating their genomes, one that supports virus production during active or "lytic" infection, and a second one that operates during latent stages of infecti
Architecture of replication compartments formed during Epstein-Barr virus lytic replication.
Epstein-Barr virus (EBV) productive DNA replication occurs at discrete sites, called replication compartments, in nuclei. In this study we performed comprehensive analyses of the architecture of the replication compartments. The BZLF1 oriLyt binding proteins showed a fine, diffus
Evidence for Sequential and Increasing Activation of Replication Origins along Replication Timing Gradients in the Human Genome
Genome-wide replication timing studies have suggested that mammalian chromosomes consist of megabase-scale domains of coordinated origin firing separated by large originless transition regions. Here, we report a quantitative genome-wide analysis of DNA replication kinetics in sev
EEPD1: Breaking and Rescuing the Replication Fork
The faithful duplication of an entire genome is a complex affair requiring the coordinated action of the DNA replisome to unwind and synthesize DNA at replication forks. Unfortunately, exposure to chemicals or radiation can damage DNA strands, and this damage can stall DNA replic
Spontaneous emergence of self-replication in chemical reaction systems
Self-replication is one of the central properties of life (1), and to explain life’s origins we need to explain how selfreplication arose. It is widely accepted that before DNA, life replicated through RNA molecules (2). However, it remains unclear how the building blocks of RNA,