Ketotifen is a benzocycloheptathiophene with a range of pharmacological activities. The present study was carried out to evaluate the action of ketotifen on isolated rat bladder contractions induced by KCI and acetylcholine, compared with the effects of other drugs. Ketotifen (5 µM) reduced the response to acetylcholine on rat isolated bladder without altering the maximum response and shift...

OBJECTIVES In JIA there is an unmet need for biomarkers with which to identify patients who will respond well to MTX. The aim of this study was to define the prognostic value of baseline serum proteins and clinical variables in response to MTX to help inform the clinician at time of diagnosis whether the patient is likely to respond well to MTX. METHODS JIA patients were recruited into the Ch...

epidemiological indices of 39 subjects with autoimmune hepatitis and their response to treatment in iran

background recently the prevalence of obesity and its comorbidities has increased in children, in the worldwide. some evidences show that there is a reverse relation between the serum level of 25-hydroxyvitamin d[25(oh)d] and body mass index (bmi). the purpose of this study was scrutiny response to treatment vitamin d deficiency in obese/overweight children. materials and methods  in this cross...

objective: the purpose of this study was to evaluate the effect of treatment on reducing the additional psychiatric symptoms in a sample of recovered depressed patients. methods: a sample of 354 remitted depressed subjects recruited through community advertisement and clinical practices of psychiatrists and psychotherapists were randomly assigned to mindfulness based cognitive therapy (mbct), c...

background: tumor response after multimodality treatment using combination of radiation, chemotherapeutic drugs and hyperthermia usually assessed by parameters such as tumor growth delay, volume doubling time and regression response. the study herein was conducted to investigate the usefulness of micronucleus assay for assessing the multimodality treatment. materials and methods: the induction ...

Background: To design a pre-Ovsynch hormonal strategy in yaks in order to increase the ovulatory response to the first GnRH injection of Ovsynch so that overall synchronization rate to Ovsynch could be improved. Materials and Methods: Non-lactating cyclic yak cows (n=33) were assigned to receive either no treatment before Ovsynch (control) or 0.375mg of PGF2(PreP) followed 2 d later by 10 g of ...

myelin basic protein (mbp) is one of the most important constituents of the cns myelin sheaths. it is supposed that an autoimmune response directed against mbp is crucial in the demyelination process in patients with multiple sclerosis. studies have proved that free anti-mbp level in csf of ms patients is declined when the patient entered into clinical remission. some researchers evaluate the c...