TOPIC: Critical Care TYPE: Medical Student/Resident Case Reports INTRODUCTION: Rhinocerebral mucormycosis is a fatal infection in poorly controlled diabetic patients with history of ketoacidosis (DKA). DKA blunts neutrophil chemotaxis, phagocytosis and boosts serum iron, mucor nutrient. It spreads to the brain via hematogenous or contiguous spread [1]. We present case disseminated rhinocerebral...

Figure 1. Total WBC count (0) and ANC (e) for patient 1, a 37year-old male who developed vancomycin-induced neutropenia. G-CSF (600 f.Lg iv) was initially administered on days 30 and 33 of therapy. Additional 300-f.Lg doses of iv G-CSF were administered twice weekly (on days 38-52) and thrice weekly (on days 55-78) until vancomycin therapy was completed. ANC = absolute neutrophil count. 8,500

The most common clinical presentation of mucormycosis is rhino-orbital-cerebral infection, which is supposed to begin with inhalation of spores into the paranasal sinuses of a vulnerable host. Hyperglycemia, with an associated metabolic acidosis, is the most common underlying state.1 The hallmarks of spread outside the sinuses are tissue necrosis of the palate.1,2 We present a 57-year-old man a...

NCCLS, Villanova, PA, USA, 2001. 3. Weill FX, Bertrand S, Guesnier F et al. Ciprofloxacinresistant Salmonella Kentucky in travelers. Emerg Infect Dis 2006; 12: 1611–2. 4. Baucheron S, Imberechts H, Chaslus-Dancla E et al. The AcrB multidrug transporter plays a major role in high-level fluoroquinolone resistance in Salmonella enterica serovar Typhimurium phage type DT204. Microb Drug Resist 2002...

Genera of the order Mucorales (Rhizopus, Mucor, Rhizomucor, Absidia, Apophysomyces, Cunninghamella, and Saksenaea) cause an angioinvasive infection called zygomycosis. Mortality rates can approach 100% depending on the patient's underlying disease and form of zygomycosis. We report here on the unusual case of a patient with acute myelogenous leukemia and zygomycosis unresponsive to monotherapy ...

BACKGROUND Mucormycosis (or zygomycosis) is the term for infection caused by fungi of the order Mucorales. Mucoraceae may produce severe disease in susceptible individuals, notably patients with diabetes and leukemia. Rhinocerebral mucormycosis most commonly manifests itself in the setting of poorly controlled diabetes, especially with ketoacidosis. CASE PRESENTATION A 31-year-old diabetic ma...

This study reports a case of an immunocompetent patient with right lateral rectus palsy secondary to mucormycosis infection in the sphenoid and ethmoid sinuses extending to the carvenous sinus. The patient used for this study is a healthy, well built and well nourished 14 year old girl presented with symptom of headache of 2 weeks duration. Complaint of diplopia was made on day one of admission...