drug interaction may cause sever adverse drug reactions in patients. the high amounts of prescribed medication in hospitalized patients will cause higher incidence of drug interactions. therefore, the study of drug interactions in hospitalized patients seems to be worth. we have, studied drug interaction in internal and surgical units, in kashani hospital in shahrekord. factors included in this...

abstract background: the increase in breast cancer incidence has enhanced attention towards breast cancer risk. the aim of this study was to determine the risk of breast cancer and risk perception of women, factors that affect risk perception, and to determine differences between absolute risk and the perception of risk. methods: this cross-sectional study was carried out among 346 women whose ...

Atrial Fibrillation (AF) is the most common dysrhythmia seen in primary care. Thromboembolic stroke remains one of the most feared complications of this rhythm disturbance. Five landmark trials have demonstrated the efficacy of warfarin and aspirin in reducing this risk. Warfarin use is known to be labor intensive for patients and concerns regarding multiple drug interactions and bleed risk hav...

Background: Protein-protein interactions do not provide any direct information re‌garding the domains within the proteins that mediate the interactions. The majority of proteins are multi domain proteins and the interaction between them is often defined by the pairs of their domains. Most of the former studies focus only on interacting do‌main pairs. However they do not consider the in...

Emerging data suggest that the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) offer important benefits for the large population of individuals at high risk for coronary heart disease. This population encompasses a sizable portion of individuals who are also at high risk for drug-drug interactions due to their need for multiple medications. In general, statins are...

Background and Objectives: Arteriovenous fistula is a popular vascular access method for surgical treatment of hemodialysis patients. The method, however, is associated with a high rate of early failure varying in the range of 20-60%. Predicting early Arteriovenous fistula failure and its risk factors can help reduce its incidence, its hospitalization rate, and associated costs. In this study, ...

Coronary heart disease (CHD) is a major cause of death worldwide. In the U.S. CHD is responsible for approximated 1 in every 6 deaths with a coronary event occurring every 25 seconds and about 1 death every minute based on data current to 2007. Although a multitude of cardiovascular risks factors have been identified, CHD actually reflects complex interactions of these factors over time. Today’...

OBJECTIVE The identification of gene-gene interactions has been limited by small sample size and large number of potential interactions between genes. To address this issue, Ritchie et al. [2001] have proposed multifactor dimensionality reduction (MDR) method to detect polymorphisms associated with the disease risk. The MDR reduces the dimension of the genetic factors by classifying them into h...