236 Introduction: 750 Discussion: 1155 1 Abbreviations used are: m/z, mass-to-charge ratio; HLM, human liver microsome; RLM, rat liver microsome; CYP, cytochrome P450, UDPGA, uridine 5’-diphosphoglucuronic acid This article has not been copyedited and formatted. The final version may differ from this version. DMD Fast Forward. Published on October 7, 2009 as DOI: 10.1124/dmd.109.028449 at A PE ...

Background & Aims: Magnetically molecularly imprinted polymers (MMIPs) are assumed as kind of sorbent polymers ‎which can separate or determine bioactive compounds from environment fast and specifically.  ‎Magnetic properties, stability at various conditions (temperature , ionic strength and pH) and selective ‎function are among the advantages of these polymers in determin...

To accurately predict the modifications done during metabolic processes by cytochrome P450 (P450) 3A enzyme, selecting substrates that best represent a broad range of substrate substitutions and that follow the Michaelis-Menten kinetic properties is highly necessary. In the present study, the oxidative pathways of deoxyschizandrin (DS), the most abundant lignan in Fructus Schisandrae fruit extr...

A rapid induction of effector functions in memory T cells provides rapid and intensified protection against reinfection. To determine potential roles of IL-15 in early expansion and activation of memory CD8+ T cells in secondary immune response, we examined the cell division and cytotoxicity of memory CD8+ T cells expressing OVA(257-264)/Kb-specific TCR that were transferred into IL-15-transgen...

Specific detection of mRNA cleavage by 5'RACE is the only method to confirm the knockdown of mRNA by RNA interference, but is rarely reported for in vivo studies. We have combined 5'-RNA-linker-mediated RACE (5'-RLM-RACE) with real-time PCR using a molecular beacon to develop a rapid and specific method termed MBRACE, which we have used to detect small-interfering RNA (siRNA)-induced cleavage o...

O estudo investigou aspectos da evasão e avaliou a satisfação de calouros no curso Odontologia uma instituição ensino superior pública, além relatar intervenções combate ao abandono acadêmico desenvolvidas neste período. Trata-se um com fase observacional, transversal, descritiva, quanti-qualitativa, aplicação questionários; outra intervencionista, atividades voltadas à evasão. Foram entrevista...

We present a nonperturbative and formally exact approach for the charge transport in interacting nanojunctions based on real-time path-integral formulation of reduced system dynamics. For reservoirs noninteracting fermions, trace over leads' degrees freedom results time-nonlocal Feynman-Vernon influence functional, functional Grassmann-valued paths nanojunction, which induces correlations among...

Geographical Information System (GIS) always plays an integral role in LBS systems. But it comes with technology problems, such as less flexible, low efficiency, no redundancy of existing geographic information of application configuration which has high entry cost. At same time, indoors positioning is attracting more and more attention from research domain where GPS-like systems do not work. B...

This research aims to develop a portable haptic master hand with 20 degrees of freedom (DOF). Master hands are used as haptic interfaces in master-slave systems. A master-slave system consists of a haptic interface that communicates with a virtual world or an end-effector for tele-operation, such as a robot hand. The thumb and fingers are usually modeled as a serial linkage mechanism with 4 DOF...